bis{4-[N-(N-methylpiperazinyl)methyl]phenyl}phosphine oxide

Base Information

• Chemical Name: bis{4-[N-(N-methylpiperazinyl)methyl]phenyl}phosphine oxide
• CAS No.: 1275579-59-3
• Molecular Formula: C₂₄H₃₅N₄OP
• Molecular Weight: 426.542
• Mol file: 1275579-59-3.mol

Synonyms:bis{4-[N-(N-methylpiperazinyl)methyl]phenyl}phosphine oxide

Chemical Property of bis{4-[N-(N-methylpiperazinyl)methyl]phenyl}phosphine oxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of bis{4-[N-(N-methylpiperazinyl)methyl]phenyl}phosphine oxide

There total 3 articles about bis{4-[N-(N-methylpiperazinyl)methyl]phenyl}phosphine oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

4-[(4-methylpiperazin-1-yl)methyl]bromobenzene (368879-17-8) → bis{4-[N-(N-methylpiperazinyl)methyl]phenyl}phosphine oxide (1275579-59-3)

Guidance literature:

4-[(4-methylpiperazin-1-yl)methyl]bromobenzene; With iodine; magnesium; In tetrahydrofuran; at 0 - 20 ℃;

With phosphonic acid diethyl ester; In tetrahydrofuran; for 2h; Reflux;

DOI:10.1039/c0cc04196c

Reference yield:

1-methyl-piperazine (109-01-3) → bis{4-[N-(N-methylpiperazinyl)methyl]phenyl}phosphine oxide (1275579-59-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 1,4-dioxane / 0 - 25 °C

2.1: iodine; magnesium / tetrahydrofuran / 0 - 20 °C

2.2: 2 h / Reflux

With iodine; magnesium; In tetrahydrofuran; 1,4-dioxane;

DOI:10.1039/c0cc04196c

Reference yield:

1-bromomethyl-4-bromobenzene (589-15-1) → bis{4-[N-(N-methylpiperazinyl)methyl]phenyl}phosphine oxide (1275579-59-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 1,4-dioxane / 0 - 25 °C

2.1: iodine; magnesium / tetrahydrofuran / 0 - 20 °C

2.2: 2 h / Reflux

With iodine; magnesium; In tetrahydrofuran; 1,4-dioxane;

DOI:10.1039/c0cc04196c

upstream raw materials:

1-methyl-piperazine

4-[(4-methylpiperazin-1-yl)methyl]bromobenzene

1-bromomethyl-4-bromobenzene

Downstream raw materials:

bis{4-[N-(N-methylpiperazinyl)methyl]phenyl}phosphine