4,6,7-Trimethoxy-3-<2-<<<2-(trimethylsilyl)ethoxy>carbonyl>amino>ethyl>-1-(p-toluenesulfonyl)indole

Base Information

• Chemical Name: 4,6,7-Trimethoxy-3-<2-<<<2-(trimethylsilyl)ethoxy>carbonyl>amino>ethyl>-1-(p-toluenesulfonyl)indole
• CAS No.: 161156-08-7
• Molecular Formula: C₂₆H₃₆N₂O₇SSi
• Molecular Weight: 548.733
• Mol file: 161156-08-7.mol

Synonyms:4,6,7-Trimethoxy-3-<2-<<<2-(trimethylsilyl)ethoxy>carbonyl>amino>ethyl>-1-(p-toluenesulfonyl)indole

Chemical Property of 4,6,7-Trimethoxy-3-<2-<<<2-(trimethylsilyl)ethoxy>carbonyl>amino>ethyl>-1-(p-toluenesulfonyl)indole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4,6,7-Trimethoxy-3-<2-<<<2-(trimethylsilyl)ethoxy>carbonyl>amino>ethyl>-1-(p-toluenesulfonyl)indole

There total 1 articles about 4,6,7-Trimethoxy-3-<2-<<<2-(trimethylsilyl)ethoxy>carbonyl>amino>ethyl>-1-(p-toluenesulfonyl)indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(Trimethylsilyl)ethyl 4-nitrophenyl carbonate (80149-80-0) + 1-(p-Toluenesulfonyl)-4,6,7-trimethoxytryptamine (161156-06-5) → 4,6,7-Trimethoxy-3-<2-<<<2-(trimethylsilyl)ethoxy>carbonyl>amino>ethyl>-1-(p-toluenesulfonyl)indole (161156-08-7)

Guidance literature:

With triethylamine; In acetonitrile; for 8h; Yield given; Heating;

DOI:10.1021/jo00111a043

Reference yield: 78.0%

4,6,7-Trimethoxy-3-<2-<<<2-(trimethylsilyl)ethoxy>carbonyl>amino>ethyl>-1-(p-toluenesulfonyl)indole (161156-08-7) → 6-Methoxy-3-<2-<<<2-(trimethylsilyl)ethoxy>carbonyl>amino>ethyl>-1-(p-toluenesulfonyl)indole-4,7-dione (138540-75-7)

Guidance literature:

With ammonium cerium(IV) nitrate; tetra(n-butyl)ammonium hydrogensulfate; In dichloromethane; for 0.583333h;

DOI:10.1021/jo00111a043

Reference yield: 23.0%

4,6,7-Trimethoxy-3-<2-<<<2-(trimethylsilyl)ethoxy>carbonyl>amino>ethyl>-1-(p-toluenesulfonyl)indole (161156-08-7) → 6-Methoxy-3-<2-<<<2-(trimethylsilyl)ethoxy>carbonyl>amino>ethyl>-1-(p-toluenesulfonyl)indole-4,7-dione (138540-75-7) + {2-[4,6,7-Trimethoxy-2-nitro-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-ethyl}-carbamic acid 2-trimethylsilanyl-ethyl ester

Guidance literature:

With ammonium cerium(IV) nitrate; tetra(n-butyl)ammonium hydrogensulfate; In dichloromethane; for 0.583333h;

DOI:10.1021/jo00111a043

upstream raw materials:

2-(Trimethylsilyl)ethyl 4-nitrophenyl carbonate

1-(p-Toluenesulfonyl)-4,6,7-trimethoxytryptamine

Downstream raw materials:

6-Methoxy-3-<2-<<<2-(trimethylsilyl)ethoxy>carbonyl>amino>ethyl>-1-(p-toluenesulfonyl)indole-4,7-dione