methyl 2-(4-(4-cyanophenyl)-2,5-dioxo-1-(3-(trifluoromethyl)phenyl)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-3(2H,4H,5H)-yl)acetate

Base Information

Chemical Name:methyl 2-(4-(4-cyanophenyl)-2,5-dioxo-1-(3-(trifluoromethyl)phenyl)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-3(2H,4H,5H)-yl)acetate
CAS No.:1621269-94-0
Molecular Formula:C₂₄H₁₈F₃N₃O₄
Molecular Weight:469.42
Hs Code.:

Synonyms:methyl 2-(4-(4-cyanophenyl)-2,5-dioxo-1-(3-(trifluoromethyl)phenyl)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-3(2H,4H,5H)-yl)acetate

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Chemical Property of methyl 2-(4-(4-cyanophenyl)-2,5-dioxo-1-(3-(trifluoromethyl)phenyl)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-3(2H,4H,5H)-yl)acetate

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Technology Process of methyl 2-(4-(4-cyanophenyl)-2,5-dioxo-1-(3-(trifluoromethyl)phenyl)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-3(2H,4H,5H)-yl)acetate

There total 10 articles about methyl 2-(4-(4-cyanophenyl)-2,5-dioxo-1-(3-(trifluoromethyl)phenyl)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-3(2H,4H,5H)-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1621269-89-3
4-(2,5-dioxo-1-(3-(trifluoromethyl)phenyl)-2,3,4,5,6,7-hexahydro-1H-cyclopenta[d]-pyrimidin-4-yl)benzonitrile

: 96-32-2
bromoacetic acid methyl ester

: 1621269-94-0
methyl 2-(4-(4-cyanophenyl)-2,5-dioxo-1-(3-(trifluoromethyl)phenyl)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-3(2H,4H,5H)-yl)acetate

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; acetonitrile; at 5 ℃; for 1.5h;

Reference yield:

: 3-[[3-(trifluoromethyl)phenyl]amino]-2-cyclopenten-1-one

: 1621269-94-0
methyl 2-(4-(4-cyanophenyl)-2,5-dioxo-1-(3-(trifluoromethyl)phenyl)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-3(2H,4H,5H)-yl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane / 20 °C / Reflux

2: lithium diisopropyl amide / tetrahydrofuran; acetonitrile / 1.5 h / 5 °C

With lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; acetonitrile;

Reference yield:

: 105-07-7
4-cyanobenzaldehyde

: 1621269-94-0
methyl 2-(4-(4-cyanophenyl)-2,5-dioxo-1-(3-(trifluoromethyl)phenyl)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-3(2H,4H,5H)-yl)acetate

Guidance literature:: Multi-step reaction with 4 steps

1: calcium chloride; sulfuric acid / 7 h / 145 °C / Inert atmosphere

2: phosphorus pentachloride / benzene / 2 h / Reflux

3: dichloromethane / 20 °C / Reflux

4: lithium diisopropyl amide / tetrahydrofuran; acetonitrile / 1.5 h / 5 °C

With phosphorus pentachloride; sulfuric acid; calcium chloride; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; acetonitrile; benzene;