3-(2-acetylamino-5-trimethylsilanylethynyl-phenylethynyl)-5-trimethylsilanylethynyl-benzoic acid methyl ester

Base Information

Chemical Name:3-(2-acetylamino-5-trimethylsilanylethynyl-phenylethynyl)-5-trimethylsilanylethynyl-benzoic acid methyl ester
CAS No.:488082-68-4
Molecular Formula:C₂₈H₃₁NO₃Si₂
Molecular Weight:485.73
Hs Code.:

Synonyms:3-(2-acetylamino-5-trimethylsilanylethynyl-phenylethynyl)-5-trimethylsilanylethynyl-benzoic acid methyl ester

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Chemical Property of 3-(2-acetylamino-5-trimethylsilanylethynyl-phenylethynyl)-5-trimethylsilanylethynyl-benzoic acid methyl ester

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Technology Process of 3-(2-acetylamino-5-trimethylsilanylethynyl-phenylethynyl)-5-trimethylsilanylethynyl-benzoic acid methyl ester

There total 6 articles about 3-(2-acetylamino-5-trimethylsilanylethynyl-phenylethynyl)-5-trimethylsilanylethynyl-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1066-54-2
trimethylsilylacetylene

: 488082-67-3
3-(2-acetylamino-5-iodo-phenylethynyl)-5-iodo-benzoic acid methyl ester

: 488082-68-4
3-(2-acetylamino-5-trimethylsilanylethynyl-phenylethynyl)-5-trimethylsilanylethynyl-benzoic acid methyl ester

Guidance literature:: With copper(l) iodide; triethylamine; triphenylphosphine; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; at 50 ℃; for 26h;
DOI:10.1021/ol0270982

Reference yield:

: 13296-94-1
2-bromo-4-nitroaniline

: 488082-68-4
3-(2-acetylamino-5-trimethylsilanylethynyl-phenylethynyl)-5-trimethylsilanylethynyl-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: 88 percent / Cu(OTf)2 / CH₂Cl₂

2.1: 73 percent / HCO₂H; Et₃N / Pt/C / 50 - 80 °C

3.1: NaNO₂; HCl / H₂O; acetonitrile / 0.5 h / 5 °C

3.2: 0.58 percent / K₂CO₃ / H₂O

4.1: 95 percent / CuI; PPh₃; Et₃N / Pd₂(dba)3 / 36 h / 70 °C

5.1: TBAF / tetrahydrofuran

6.1: 0.309 g / CuI; PPh₃; Et₃N / Pd₂(dba)3 / 24 h / 70 °C

7.1: 70 percent / MeI / 17 h / 110 °C

8.1: 94 percent / CuI; PPh₃; Et₃N / Pd₂(dba)3 / 26 h / 50 °C

With hydrogenchloride; copper(l) iodide; formic acid; tetrabutyl ammonium fluoride; copper(II) bis(trifluoromethanesulfonate); triethylamine; triphenylphosphine; sodium nitrite; methyl iodide; platinum on activated charcoal; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In tetrahydrofuran; dichloromethane; water; acetonitrile;
DOI:10.1021/ol0270982

Reference yield:

: 436090-22-1
N-(4-amino-2-bromophenyl)acetamide

: 488082-68-4
3-(2-acetylamino-5-trimethylsilanylethynyl-phenylethynyl)-5-trimethylsilanylethynyl-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: NaNO₂; HCl / H₂O; acetonitrile / 0.5 h / 5 °C

1.2: 0.58 percent / K₂CO₃ / H₂O

2.1: 95 percent / CuI; PPh₃; Et₃N / Pd₂(dba)3 / 36 h / 70 °C

3.1: TBAF / tetrahydrofuran

4.1: 0.309 g / CuI; PPh₃; Et₃N / Pd₂(dba)3 / 24 h / 70 °C

5.1: 70 percent / MeI / 17 h / 110 °C

6.1: 94 percent / CuI; PPh₃; Et₃N / Pd₂(dba)3 / 26 h / 50 °C

With hydrogenchloride; copper(l) iodide; tetrabutyl ammonium fluoride; triethylamine; triphenylphosphine; sodium nitrite; methyl iodide; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In tetrahydrofuran; water; acetonitrile;
DOI:10.1021/ol0270982