rel-(1R,2R)-2-(1-Methylethyl)-1-[[(phenylmethoxy)carbonyl]amino]cyclopropanecarboxylic acid

Base Information

Chemical Name:rel-(1R,2R)-2-(1-Methylethyl)-1-[[(phenylmethoxy)carbonyl]amino]cyclopropanecarboxylic acid
CAS No.:123311-19-3
Molecular Formula:C₁₅H₁₉NO₄
Molecular Weight:277.32
Hs Code.:
DSSTox Substance ID:DTXSID201120778

Synonyms:DTXSID201120778;rel-(1R,2R)-2-(1-Methylethyl)-1-[[(phenylmethoxy)carbonyl]amino]cyclopropanecarboxylic acid;123311-19-3

Suppliers and Price of rel-(1R,2R)-2-(1-Methylethyl)-1-[[(phenylmethoxy)carbonyl]amino]cyclopropanecarboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of rel-(1R,2R)-2-(1-Methylethyl)-1-[[(phenylmethoxy)carbonyl]amino]cyclopropanecarboxylic acid

Chemical Property:

XLogP3:2.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:277.13140809
Heavy Atom Count:20
Complexity:376

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)C1CC1(C(=O)O)NC(=O)OCC2=CC=CC=C2
Isomeric SMILES:CC(C)[C@H]1C[C@@]1(C(=O)O)NC(=O)OCC2=CC=CC=C2

Technology Process of rel-(1R,2R)-2-(1-Methylethyl)-1-[[(phenylmethoxy)carbonyl]amino]cyclopropanecarboxylic acid

There total 4 articles about rel-(1R,2R)-2-(1-Methylethyl)-1-[[(phenylmethoxy)carbonyl]amino]cyclopropanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.4%

: 123311-16-0
N-(benzyloxycarbonyl)-(Z)-2,3-methanoleucine p-nitrobenzyl ester

: 123311-19-3
N-(benzyloxycarbonyl)-(Z)-2,3-methanoleucine

Guidance literature:: With potassium hydroxide; In methanol; for 24h; Ambient temperature;
DOI:10.1021/jo00286a015

Reference yield:

: 52715-73-8
N-(benzyloxycarbonyl)dehydroalanine p-nitrobenzyl ester

: 123311-19-3
N-(benzyloxycarbonyl)-(Z)-2,3-methanoleucine

Guidance literature:: Multi-step reaction with 3 steps

1: 74.6 percent / diethyl ether; CH₂Cl₂ / 1 h / -15 - -12 °C

2: 31.5 percent / benzene / 4.5 h / Heating

3: 35.4 percent / 3 N KOH / methanol / 24 h / Ambient temperature

With potassium hydroxide; In methanol; diethyl ether; dichloromethane; benzene;
DOI:10.1021/jo00286a015

Reference yield:

: 123311-12-6
N-(benzyloxycarbonyl)-DL-serine p-nitrobenzyl ester

: 123311-19-3
N-(benzyloxycarbonyl)-(Z)-2,3-methanoleucine

Guidance literature:: Multi-step reaction with 4 steps

1: 44.4 percent / CuCl, 1-(3-(dimethylamino)propyl)-3-ethylcarbodiimide (EDC) / CHCl₃ / 6 h / Ambient temperature

2: 74.6 percent / diethyl ether; CH₂Cl₂ / 1 h / -15 - -12 °C

3: 31.5 percent / benzene / 4.5 h / Heating

4: 35.4 percent / 3 N KOH / methanol / 24 h / Ambient temperature

With potassium hydroxide; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; copper(l) chloride; In methanol; diethyl ether; dichloromethane; chloroform; benzene;
DOI:10.1021/jo00286a015