trimethoxy(2-methylphenyl)silane

Base Information

• Chemical Name: trimethoxy(2-methylphenyl)silane
• CAS No.: 158715-24-3
• Molecular Formula: C₁₀H₁₆O₃Si
• Molecular Weight: 212.321
• Mol file: 158715-24-3.mol

Synonyms:trimethoxy(2-methylphenyl)silane

Chemical Property of trimethoxy(2-methylphenyl)silane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trimethoxy(2-methylphenyl)silane

There total 2 articles about trimethoxy(2-methylphenyl)silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tetramethylorthosilicate (681-84-5) + 2-methylphenyl bromide (95-46-5) → trimethoxy(2-methylphenyl)silane (158715-24-3)

Guidance literature:

2-methylphenyl bromide; With magnesium; In tetrahydrofuran; at 20 ℃;

tetramethylorthosilicate; In tetrahydrofuran; at -30 - 20 ℃; for 13h;

DOI:10.1021/jo048667h

Reference yield:

tetramethylorthosilicate (681-84-5) → trimethoxy(2-methylphenyl)silane (158715-24-3)

Guidance literature:

In tetrahydrofuran; at -30 - 20 ℃; for 13h; Inert atmosphere;

DOI:10.1021/acs.orglett.0c00631

Reference yield: 93.0%

phenylacetylene (536-74-3) + trimethoxy(2-methylphenyl)silane (158715-24-3) → 1-phenylethynyltoluene (14309-60-5)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; silver fluoride; sodium hydrogencarbonate; In acetonitrile; at 20 ℃; for 3h;

DOI:10.1016/j.tetlet.2008.11.049

upstream raw materials:

tetramethylorthosilicate

2-methylphenyl bromide

Downstream raw materials:

1-phenylethynyltoluene

2-(2-methylphenyl)naphthalene

1-(2-Methylphenyl)-1,2-diphenylethen

N-phenyl-2-methylaniline

Refernces

• 1、 Lu, Ming-Zhu,Ding, Xin,Shao, Changdong,Hu, Zhengsong,Luo, Haiqing,Zhi, Sanjun,Hu, Huayou,Kan, Yuhe,Loh, Teck-Peng. "Direct Hiyama Cross-Coupling of (Hetero)arylsilanes with C(sp2)-H Bonds Enabled by Cobalt Catalysis". supporting information. p. 2663 - 2668. Retrieved 2020/03/30.