3-(tert-Butylamino-methyl)-5-(7-chloro-quinolin-4-ylamino)-4'-fluoro-biphenyl-2-ol

Base Information

Chemical Name:3-(tert-Butylamino-methyl)-5-(7-chloro-quinolin-4-ylamino)-4'-fluoro-biphenyl-2-ol
CAS No.:79287-22-2
Molecular Formula:C₂₆H₂₅ClFN₃O
Molecular Weight:449.955
Hs Code.:

Synonyms:3-(tert-Butylamino-methyl)-5-(7-chloro-quinolin-4-ylamino)-4'-fluoro-biphenyl-2-ol

Suppliers and Price of 3-(tert-Butylamino-methyl)-5-(7-chloro-quinolin-4-ylamino)-4'-fluoro-biphenyl-2-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(tert-Butylamino-methyl)-5-(7-chloro-quinolin-4-ylamino)-4'-fluoro-biphenyl-2-ol

Chemical Property:

Purity/Quality:

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Technology Process of 3-(tert-Butylamino-methyl)-5-(7-chloro-quinolin-4-ylamino)-4'-fluoro-biphenyl-2-ol

There total 6 articles about 3-(tert-Butylamino-methyl)-5-(7-chloro-quinolin-4-ylamino)-4'-fluoro-biphenyl-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 459-03-0
4-fluorophenyl acetone

: 79287-22-2
3-(tert-Butylamino-methyl)-5-(7-chloro-quinolin-4-ylamino)-4'-fluoro-biphenyl-2-ol

Guidance literature:: Multi-step reaction with 6 steps

1: 80 percent / aq. sodium hydroxide / ethanol / 20 h

2: H₂ / Raney nickel / methanol

3: methanol

4: ethanol; H₂O / Heating

5: 6 N aq. HCl / Heating

6: ethanol / Heating

With hydrogenchloride; sodium hydroxide; hydrogen; nickel; In methanol; ethanol; water;
DOI:10.1021/jm00156a009

Reference yield:

: 79287-47-1
2-(4-fluorophenyl)-4-nitrophenol

: 79287-22-2
3-(tert-Butylamino-methyl)-5-(7-chloro-quinolin-4-ylamino)-4'-fluoro-biphenyl-2-ol

Guidance literature:: Multi-step reaction with 5 steps

1: H₂ / Raney nickel / methanol

2: methanol

3: ethanol; H₂O / Heating

4: 6 N aq. HCl / Heating

5: ethanol / Heating

With hydrogenchloride; hydrogen; nickel; In methanol; ethanol; water;
DOI:10.1021/jm00156a009

Reference yield:

: 405-50-5
p-Fluorophenylacetic acid

: 79287-22-2
3-(tert-Butylamino-methyl)-5-(7-chloro-quinolin-4-ylamino)-4'-fluoro-biphenyl-2-ol

Guidance literature:: Multi-step reaction with 7 steps

1: 94 percent / lithium bromide / tetrahydrofuran; diethyl ether / 1 h / Heating

2: 80 percent / aq. sodium hydroxide / ethanol / 20 h

3: H₂ / Raney nickel / methanol

4: methanol

5: ethanol; H₂O / Heating

6: 6 N aq. HCl / Heating

7: ethanol / Heating

With hydrogenchloride; sodium hydroxide; hydrogen; lithium bromide; nickel; In tetrahydrofuran; methanol; diethyl ether; ethanol; water;
DOI:10.1021/jm00156a009