4-vinyl-3,6-dihydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester

Base Information

• Chemical Name: 4-vinyl-3,6-dihydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester
• CAS No.: 706808-71-1
• Molecular Formula: C₁₉H₂₄N₂O₄
• Molecular Weight: 344.411

Synonyms:4-vinyl-3,6-dihydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester

Chemical Property of 4-vinyl-3,6-dihydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester

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Technology Process of 4-vinyl-3,6-dihydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester

There total 3 articles about 4-vinyl-3,6-dihydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

C19H24N2O4 (706808-60-8) → 4-vinyl-3,6-dihydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester (706808-71-1)

Guidance literature:

Grubbs catalyst first generation; In dichloromethane; at 45 ℃; for 4h;

DOI:10.1016/j.tetlet.2004.03.075

Reference yield:

1-tert-butoxycarbonyl-2-carbobenzyloxyhydrazine (57699-88-4) → 4-vinyl-3,6-dihydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester (706808-71-1)

Guidance literature:

Multi-step reaction with 3 steps

1: NaH; n-Bu₄NI / dimethylformamide / 25 °C

2: NaH; n-Bu₄NI / dimethylformamide / 25 °C

3: 99 percent / Grubbs' catalyst / CH₂Cl₂ / 4 h / 45 °C

With tetra-(n-butyl)ammonium iodide; sodium hydride; Grubbs catalyst first generation; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.tetlet.2004.03.075

Reference yield:

N(1)-t-butyloxycarbonyl-N(2)-formylmethyl-N(2)-benzyloxycarbonyl hydrazine (192725-91-0) → 4-vinyl-3,6-dihydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester (706808-71-1)

Guidance literature:

Multi-step reaction with 2 steps

1: NaH; n-Bu₄NI / dimethylformamide / 25 °C

2: 99 percent / Grubbs' catalyst / CH₂Cl₂ / 4 h / 45 °C

With tetra-(n-butyl)ammonium iodide; sodium hydride; Grubbs catalyst first generation; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.tetlet.2004.03.075

upstream raw materials:

C₁₉H₂₄N₂O₄

1-tert-butoxycarbonyl-2-carbobenzyloxyhydrazine

N⁽¹⁾-t-butyloxycarbonyl-N⁽²⁾-formylmethyl-N⁽²⁾-benzyloxycarbonyl hydrazine

Downstream raw materials:

1,4,4a,7-tetrahydro-phthalazine-2,3,5,6-tetracarboxylic acid 3-benzyl ester 2-tert-butyl ester 5,6-dimethyl ester

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