6-butyl-2-methyl-3-(2-methyl-4-(4-(trifluoromethoxy)phenoxy)phenyl)-7-(2-phenoxyethoxy)quinolin-4(1H)-one

Base Information

Chemical Name:6-butyl-2-methyl-3-(2-methyl-4-(4-(trifluoromethoxy)phenoxy)phenyl)-7-(2-phenoxyethoxy)quinolin-4(1H)-one
CAS No.:1349820-87-6
Molecular Formula:C₃₆H₃₄F₃NO₅
Molecular Weight:617.665
Hs Code.:

Synonyms:6-butyl-2-methyl-3-(2-methyl-4-(4-(trifluoromethoxy)phenoxy)phenyl)-7-(2-phenoxyethoxy)quinolin-4(1H)-one

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Chemical Property of 6-butyl-2-methyl-3-(2-methyl-4-(4-(trifluoromethoxy)phenoxy)phenyl)-7-(2-phenoxyethoxy)quinolin-4(1H)-one

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Technology Process of 6-butyl-2-methyl-3-(2-methyl-4-(4-(trifluoromethoxy)phenoxy)phenyl)-7-(2-phenoxyethoxy)quinolin-4(1H)-one

There total 15 articles about 6-butyl-2-methyl-3-(2-methyl-4-(4-(trifluoromethoxy)phenoxy)phenyl)-7-(2-phenoxyethoxy)quinolin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1312077-90-9
2-methyl-4-(4-(trifluoromethoxy)penoxy)phenylboronic acid

: 1349820-59-2
6-chloro-3-ethyl-2-methyl-7-(2-morpholin-4-ylethoxy)-1H-quinolin-4-one

: 1349820-87-6
6-butyl-2-methyl-3-(2-methyl-4-(4-(trifluoromethoxy)phenoxy)phenyl)-7-(2-phenoxyethoxy)quinolin-4(1H)-one

Guidance literature:: With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In N,N-dimethyl-formamide; at 110 ℃; Inert atmosphere;
DOI:10.1021/jm200718m

Reference yield: 49.0%

: 1312077-90-9
2-methyl-4-(4-(trifluoromethoxy)penoxy)phenylboronic acid

: 1349820-67-2
6-butyl-3-iodo-2-methyl-7-(2-phenoxyethoxy)quinolin-4(1H)-one

: 1349820-87-6
6-butyl-2-methyl-3-(2-methyl-4-(4-(trifluoromethoxy)phenoxy)phenyl)-7-(2-phenoxyethoxy)quinolin-4(1H)-one

Guidance literature:: With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; at 110 ℃; Schlenk technique; Inert atmosphere; Microwave irradiation;

Reference yield:

: C₂₀H₂₉ClN₂O₄

: 1349820-87-6
6-butyl-2-methyl-3-(2-methyl-4-(4-(trifluoromethoxy)phenoxy)phenyl)-7-(2-phenoxyethoxy)quinolin-4(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: diphenylether / Reflux

2: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium phosphate / N,N-dimethyl-formamide / 110 °C / Inert atmosphere

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In diphenylether; N,N-dimethyl-formamide; 2: Suzuki coupling;
DOI:10.1021/jm200718m