5-Methyl-1-((S)-3-trityloxymethyl-cyclopent-3-enyl)-1H-pyrimidine-2,4-dione

Base Information

Chemical Name:5-Methyl-1-((S)-3-trityloxymethyl-cyclopent-3-enyl)-1H-pyrimidine-2,4-dione
CAS No.:125249-74-3
Molecular Formula:C₃₀H₂₈N₂O₃
Molecular Weight:464.564
Hs Code.:

Synonyms:5-Methyl-1-((S)-3-trityloxymethyl-cyclopent-3-enyl)-1H-pyrimidine-2,4-dione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-Methyl-1-((S)-3-trityloxymethyl-cyclopent-3-enyl)-1H-pyrimidine-2,4-dione

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Technology Process of 5-Methyl-1-((S)-3-trityloxymethyl-cyclopent-3-enyl)-1H-pyrimidine-2,4-dione

There total 7 articles about 5-Methyl-1-((S)-3-trityloxymethyl-cyclopent-3-enyl)-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 125353-61-9
carbocyclic 5'-O-trityl-3'-epi-thymidine

: 125249-74-3
5-Methyl-1-((S)-3-trityloxymethyl-cyclopent-3-enyl)-1H-pyrimidine-2,4-dione

: 125249-64-1
1-((1R,3S,4R)-3-Iodo-4-trityloxymethyl-cyclopentyl)-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: With iodine; triphenylphosphine; In dichloromethane; Ambient temperature;
DOI:10.1021/jm00167a011

Reference yield:

: 125249-58-3
(1R,2R,4R)-4-Azido-2-hydroxymethyl-cyclopentanol

: 125249-74-3
5-Methyl-1-((S)-3-trityloxymethyl-cyclopent-3-enyl)-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 5 steps

1: 83 percent / 80percent aq. NH₂NH₂*H₂O / 10percent Pd-C / methanol / 0.5 h

2: 84 percent / dimethylformamide; diethyl ether / 3.5 h / -20 °C

3: 90 percent / satd. aq. NH₃ / 2.5 h / Heating

4: 98 percent / pyridine / 5.66 h / Ambient temperature

5: 4.3 percent / I₂, triphenylphosphine (TPP) / CH₂Cl₂ / Ambient temperature

With pyridine; ammonium hydroxide; iodine; hydrazine hydrate; triphenylphosphine; palladium on activated charcoal; In methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00167a011

Reference yield:

: 125353-61-9
carbocyclic 5'-O-trityl-3'-epi-thymidine

: 125249-74-3
5-Methyl-1-((S)-3-trityloxymethyl-cyclopent-3-enyl)-1H-pyrimidine-2,4-dione

: 127589-14-4
1-((S)-3-Fluoro-3-trityloxymethyl-cyclopentyl)-5-methyl-1H-pyrimidine-2,4-dione

: 127589-13-3
1-((1R,3S,4R)-3-Fluoro-4-trityloxymethyl-cyclopentyl)-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: With 4,4'-diaminostilbene-2,2'-disulfonic acid; In dichloromethane; at -70 ℃; for 1h; Yield given. Yields of byproduct given;
DOI:10.1016/S0040-4020(01)85137-1