(2R,3S,4S,4'S)-[2-cyclohexyl-3-hydroxy-5-(4'-isopropyl-2'-oxo-oxazolidin-3'-yl)-4-methyl-5-oxo-2-pentyl]carbamic acid tert-butyl ester

Base Information

Chemical Name:(2R,3S,4S,4'S)-[2-cyclohexyl-3-hydroxy-5-(4'-isopropyl-2'-oxo-oxazolidin-3'-yl)-4-methyl-5-oxo-2-pentyl]carbamic acid tert-butyl ester
CAS No.:1315271-16-9
Molecular Formula:C₂₃H₄₀N₂O₆
Molecular Weight:440.58
Hs Code.:

Synonyms:(2R,3S,4S,4'S)-[2-cyclohexyl-3-hydroxy-5-(4'-isopropyl-2'-oxo-oxazolidin-3'-yl)-4-methyl-5-oxo-2-pentyl]carbamic acid tert-butyl ester

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Chemical Property of (2R,3S,4S,4'S)-[2-cyclohexyl-3-hydroxy-5-(4'-isopropyl-2'-oxo-oxazolidin-3'-yl)-4-methyl-5-oxo-2-pentyl]carbamic acid tert-butyl ester

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Technology Process of (2R,3S,4S,4'S)-[2-cyclohexyl-3-hydroxy-5-(4'-isopropyl-2'-oxo-oxazolidin-3'-yl)-4-methyl-5-oxo-2-pentyl]carbamic acid tert-butyl ester

There total 3 articles about (2R,3S,4S,4'S)-[2-cyclohexyl-3-hydroxy-5-(4'-isopropyl-2'-oxo-oxazolidin-3'-yl)-4-methyl-5-oxo-2-pentyl]carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 77877-19-1,165657-81-8
N-isopropyl oxazolidinone

: 160820-17-7
D-Boc-cyclohexylalaninal

: 1315271-16-9
(2R,3S,4S,4'S)-[2-cyclohexyl-3-hydroxy-5-(4'-isopropyl-2'-oxo-oxazolidin-3'-yl)-4-methyl-5-oxo-2-pentyl]carbamic acid tert-butyl ester

Guidance literature:: N-isopropyl oxazolidinone; With di-n-butylboryl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at -78 - 0 ℃; for 1h; Inert atmosphere;

D-Boc-cyclohexylalaninal; In dichloromethane; at -78 - 20 ℃; Inert atmosphere;

With dihydrogen peroxide; In methanol; at 0 ℃; for 4h;
DOI:10.1016/j.bmc.2011.04.047

Reference yield:

: 17016-83-0
(4S)-4-isopropyl-1,3-oxazolidin-2-one

: 1315271-16-9
(2R,3S,4S,4'S)-[2-cyclohexyl-3-hydroxy-5-(4'-isopropyl-2'-oxo-oxazolidin-3'-yl)-4-methyl-5-oxo-2-pentyl]carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran / -78 - 25 °C / Inert atmosphere

1.2: -78 - 25 °C / Inert atmosphere

2.1: di-n-butylboryl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / -78 - 0 °C / Inert atmosphere

2.2: -78 - 20 °C / Inert atmosphere

2.3: 4 h / 0 °C

With n-butyllithium; di-n-butylboryl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmc.2011.04.047

Reference yield:

: 127095-92-5
N-tert-butoxycarbonyl-D-cyclohexylalanine

: 1315271-16-9
(2R,3S,4S,4'S)-[2-cyclohexyl-3-hydroxy-5-(4'-isopropyl-2'-oxo-oxazolidin-3'-yl)-4-methyl-5-oxo-2-pentyl]carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / Inert atmosphere

1.2: Inert atmosphere

1.3: Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C / Inert atmosphere

3.1: di-n-butylboryl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / -78 - 0 °C / Inert atmosphere

3.2: -78 - 20 °C / Inert atmosphere

3.3: 4 h / 0 °C

With lithium aluminium tetrahydride; di-n-butylboryl trifluoromethanesulfonate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmc.2011.04.047