2-Amino-6-[[(4-fluorophenyl)-2-propynylamino]methyl]-4(3H)-quinazolinone

Base Information

Chemical Name:2-Amino-6-[[(4-fluorophenyl)-2-propynylamino]methyl]-4(3H)-quinazolinone
CAS No.:123685-52-9
Molecular Formula:C₁₈H₁₅FN₄O
Molecular Weight:322.342
Hs Code.:

Synonyms:2-Amino-6-[[(4-fluorophenyl)-2-propynylamino]methyl]-4(3H)-quinazolinone

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Chemical Property of 2-Amino-6-[[(4-fluorophenyl)-2-propynylamino]methyl]-4(3H)-quinazolinone

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Technology Process of 2-Amino-6-[[(4-fluorophenyl)-2-propynylamino]methyl]-4(3H)-quinazolinone

There total 5 articles about 2-Amino-6-[[(4-fluorophenyl)-2-propynylamino]methyl]-4(3H)-quinazolinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.8%

: 123685-45-0
N-[6-[[(4-fluorophenyl)-2-propynylamino]methyl]-3,4-dihydro-4-oxo-2-quinazolinyl]-2,2-dimethylpropanamide

: 123685-52-9
2-Amino-6-[[(4-fluorophenyl)-2-propynylamino]methyl]-4(3H)-quinazolinone

Guidance literature:: With ammonia; In methanol; for 36h; Ambient temperature;
DOI:10.1021/jm00169a040

Reference yield:

: 123685-60-9
4-fluoro-N-(prop-2-yn-1-yl)aniline

: 123685-52-9
2-Amino-6-[[(4-fluorophenyl)-2-propynylamino]methyl]-4(3H)-quinazolinone

Guidance literature:: Multi-step reaction with 2 steps

1: 80.5 percent / CaCO₃, N,N-dimethylacetamide (DMA) / 24 h / 60 °C

2: 56.8 percent / NH₃ / methanol / 36 h / Ambient temperature

With N,N-dimethyl acetamide; ammonia; calcium carbonate; In methanol;
DOI:10.1021/jm00169a040

Reference yield:

: 58677-07-9
N-[6-(bromomethyl)-3,4-dihydro-4-oxo-2-quinazolinyl]-2,2-dimethylpropanamide

: 123685-52-9
2-Amino-6-[[(4-fluorophenyl)-2-propynylamino]methyl]-4(3H)-quinazolinone

Guidance literature:: Multi-step reaction with 2 steps

1: 80.5 percent / CaCO₃, N,N-dimethylacetamide (DMA) / 24 h / 60 °C

2: 56.8 percent / NH₃ / methanol / 36 h / Ambient temperature

With N,N-dimethyl acetamide; ammonia; calcium carbonate; In methanol;
DOI:10.1021/jm00169a040