(R)-3-amino-4-phenyl-N'-(benzyloxy)-N'-methylbutanamide trifluoroacetate

Base Information

Chemical Name:(R)-3-amino-4-phenyl-N'-(benzyloxy)-N'-methylbutanamide trifluoroacetate
CAS No.:115364-79-9
Molecular Formula:C₂HF₃O₂*C₁₈H₂₂N₂O₂
Molecular Weight:412.409
Hs Code.:

Synonyms:(R)-3-amino-4-phenyl-N'-(benzyloxy)-N'-methylbutanamide trifluoroacetate

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Chemical Property of (R)-3-amino-4-phenyl-N'-(benzyloxy)-N'-methylbutanamide trifluoroacetate

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Technology Process of (R)-3-amino-4-phenyl-N'-(benzyloxy)-N'-methylbutanamide trifluoroacetate

There total 4 articles about (R)-3-amino-4-phenyl-N'-(benzyloxy)-N'-methylbutanamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 115364-77-7
(R)-N-tert-butyloxycarbonyl-3-amino-4-phenyl-N'-(benzyloxy)-N'-methylbutanamide

: 76-05-1
trifluoroacetic acid

: 115364-79-9
(R)-3-amino-4-phenyl-N'-(benzyloxy)-N'-methylbutanamide trifluoroacetate

Guidance literature:: In dichloromethane; at 0 ℃; for 1h;
DOI:10.1021/jm00117a025

Reference yield:

: 22513-22-0
N-methyl-O-benzylhydroxylamine

: 115364-79-9
(R)-3-amino-4-phenyl-N'-(benzyloxy)-N'-methylbutanamide trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1: 69 percent / triethylamine, 1-hydroxybenzotriazole hydrate, dicyclohexylcarbodiimide / CHCl₃ / 1.) 0 deg C, 1 h, 2.) room temperature, overnight

2: 89 percent / CH₂Cl₂ / 1 h / 0 °C

With 1-hydroxybenzotriazol-hydrate; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; chloroform;
DOI:10.1021/jm00117a025

Reference yield:

: 101555-61-7
(R)-3-t-butoxycarbonylamino-4-phenylbutyric acid

: 115364-79-9
(R)-3-amino-4-phenyl-N'-(benzyloxy)-N'-methylbutanamide trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1: 69 percent / triethylamine, 1-hydroxybenzotriazole hydrate, dicyclohexylcarbodiimide / CHCl₃ / 1.) 0 deg C, 1 h, 2.) room temperature, overnight

2: 89 percent / CH₂Cl₂ / 1 h / 0 °C

With 1-hydroxybenzotriazol-hydrate; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; chloroform;
DOI:10.1021/jm00117a025