C₂₁H₃₂O₈

Base Information

• Chemical Name: C₂₁H₃₂O₈
• CAS No.: 1616470-00-8
• Molecular Formula: C₂₁H₃₂O₈
• Molecular Weight: 412.48
• Mol file: 1616470-00-8.mol

Synonyms:C₂₁H₃₂O₈

Chemical Property of C₂₁H₃₂O₈

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₁H₃₂O₈

There total 9 articles about C₂₁H₃₂O₈ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C21H30O6 (1616470-14-4) → C21H32O8 (1616470-00-8) + C21H32O8

Guidance literature:

With methanesulfonamide; AD-mix β; In water; tert-butyl alcohol; at 0 - 20 ℃; Overall yield = 94 %; Overall yield = 2.52 g; diastereoselective reaction;

DOI:10.1002/anie.201402440

Reference yield:

diisopropyl (E)-hex-3-enedioate (90157-48-5) → C21H32O8 (1616470-00-8) + C21H32O8

Guidance literature:

Multi-step reaction with 6 steps

1: AD-mix β; methanesulfonamide; sodium hydrogencarbonate / water; tert-butyl alcohol / 0 °C

2: toluene-4-sulfonic acid / 20 °C / Molecular sieve

3: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 0 - 30 °C

4: manganese(IV) oxide / 1,2-dichloro-ethane / 0.83 h / 62 °C

5: lanthanum(lll) triflate / toluene / 2 h / 20 °C

6: AD-mix β; methanesulfonamide / water; tert-butyl alcohol / 0 - 20 °C

With manganese(IV) oxide; lithium aluminium tetrahydride; methanesulfonamide; AD-mix β; sodium hydrogencarbonate; toluene-4-sulfonic acid; lanthanum(lll) triflate; In tetrahydrofuran; diethyl ether; water; 1,2-dichloro-ethane; toluene; tert-butyl alcohol; 1: |Sharpless Dihydroxylation / 4: |Wittig Olefination / 6: |Sharpless Dihydroxylation;

DOI:10.1002/anie.201402440

Reference yield:

(E)-3-hexene-1,6-dioic acid (29311-53-3) → C21H32O8 (1616470-00-8) + C21H32O8

Guidance literature:

Multi-step reaction with 7 steps

1.1: acetyl chloride / 0.08 h / -5 °C / Inert atmosphere

1.2: 100 °C / Inert atmosphere

2.1: AD-mix β; methanesulfonamide; sodium hydrogencarbonate / water; tert-butyl alcohol / 0 °C

3.1: toluene-4-sulfonic acid / 20 °C / Molecular sieve

4.1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 0 - 30 °C

5.1: manganese(IV) oxide / 1,2-dichloro-ethane / 0.83 h / 62 °C

6.1: lanthanum(lll) triflate / toluene / 2 h / 20 °C

7.1: AD-mix β; methanesulfonamide / water; tert-butyl alcohol / 0 - 20 °C

With manganese(IV) oxide; lithium aluminium tetrahydride; methanesulfonamide; AD-mix β; sodium hydrogencarbonate; toluene-4-sulfonic acid; acetyl chloride; lanthanum(lll) triflate; In tetrahydrofuran; diethyl ether; water; 1,2-dichloro-ethane; toluene; tert-butyl alcohol; 2.1: |Sharpless Dihydroxylation / 5.1: |Wittig Olefination / 7.1: |Sharpless Dihydroxylation;

DOI:10.1002/anie.201402440

upstream raw materials:

diisopropyl (E)-hex-3-enedioate

(E)-3-hexene-1,6-dioic acid

diisopropyl (3R,4R)-3,4-isopropylidenehexane-1,6-dioate

diisopropyl (3R,4R)-3,4-dihydroxyhexane-1,6-dioate

Downstream raw materials:

C₂₈H₃₆O₉

(2R,3S)-1-ethoxy-3-hydroxy-4-((4R,5R)-5-(2-(4-methoxybenzyloxy)ethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)-1-oxobutan-2-yl benzoate

C₂₅H₃₂O₉

C₂₇H₃₂O₉