(3aR,4S,6S,6aR)-6-((R)-1,2-dihydroxyethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl benzoate

Base Information

Chemical Name:(3aR,4S,6S,6aR)-6-((R)-1,2-dihydroxyethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl benzoate
CAS No.:1551543-45-3
Molecular Formula:C₁₆H₂₀O₇
Molecular Weight:324.331
Hs Code.:

Synonyms:(3aR,4S,6S,6aR)-6-((R)-1,2-dihydroxyethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl benzoate

Suppliers and Price of (3aR,4S,6S,6aR)-6-((R)-1,2-dihydroxyethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl benzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3aR,4S,6S,6aR)-6-((R)-1,2-dihydroxyethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl benzoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3aR,4S,6S,6aR)-6-((R)-1,2-dihydroxyethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl benzoate

There total 1 articles about (3aR,4S,6S,6aR)-6-((R)-1,2-dihydroxyethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1551544-06-9
(3aR,4S,6S,6aR)-6-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl benzoate

: 1551543-45-3
(3aR,4S,6S,6aR)-6-((R)-1,2-dihydroxyethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl benzoate

Guidance literature:: With acetic acid; In water; at 30 ℃; for 20h;
DOI:10.1021/ol500004k

Reference yield:

: 1551543-45-3
(3aR,4S,6S,6aR)-6-((R)-1,2-dihydroxyethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl benzoate

: 1551543-54-4
(3aR,4S,6R,6aR)-6-formyl-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl benzoate

Guidance literature:: With sodium periodate; silica gel; In dichloromethane; at 20 ℃; for 0.5h;
DOI:10.1021/ol500004k

Reference yield:

: 1551543-45-3
(3aR,4S,6S,6aR)-6-((R)-1,2-dihydroxyethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl benzoate

: 1551543-73-7
(4R,5R)-(3S,4S,7R,8S,9R,10R,E)-8-((tert-butyldimethylsilyl)oxy)-10-methoxy-12-((4-methoxybenzyl)oxy)-3,5,7,9-tetramethyldodeca-1,5-dien-4-yl 2,2-dimethyl-5-((R,E)-3-methylhexa-1,5-dien-1-yl)-1,3-dioxolane-4-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium periodate; silica gel / dichloromethane / 0.5 h / 20 °C

2.1: potassium hexamethylsilazane / tetrahydrofuran / 2.25 h / 20 °C

2.2: 2 h / -78 °C

2.3: 19 h / -78 - 20 °C

3.1: sodium hydroxide; water / tetrahydrofuran; 1,4-dioxane / 0 - 20 °C

4.1: chlorodimethylsulfonium chloride / dichloromethane / 2.5 h / -78 °C

4.2: 4 h / -78 - 20 °C

5.1: copper(I) bromide dimethylsulfide complex; dimethylsulfide / tetrahydrofuran; diethyl ether / 0.25 h / -50 °C

5.2: 2 h / -50 - -15 °C

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 14 h / 20 °C / Inert atmosphere

With dmap; sodium periodate; copper(I) bromide dimethylsulfide complex; dimethylsulfide; chlorodimethylsulfonium chloride; water; silica gel; potassium hexamethylsilazane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane; 2.1: |Wittig Olefination / 4.1: |Swern Oxidation / 4.2: |Swern Oxidation;
DOI:10.1021/ol500004k