diethyl {N-[3-(hydroxymethyl)phenyl]carbamoyl}ethylphosphonate

Base Information

• Chemical Name: diethyl {N-[3-(hydroxymethyl)phenyl]carbamoyl}ethylphosphonate
• CAS No.: 1444512-12-2
• Molecular Formula: C₁₄H₂₂NO₅P
• Molecular Weight: 315.306
• Mol file: 1444512-12-2.mol

Synonyms:diethyl {N-[3-(hydroxymethyl)phenyl]carbamoyl}ethylphosphonate

Chemical Property of diethyl {N-[3-(hydroxymethyl)phenyl]carbamoyl}ethylphosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl {N-[3-(hydroxymethyl)phenyl]carbamoyl}ethylphosphonate

There total 2 articles about diethyl {N-[3-(hydroxymethyl)phenyl]carbamoyl}ethylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

3-chloro-N-[3-(hydroxymethyl)phenyl]propanamide (1153342-52-9) + triethyl phosphite (122-52-1) → diethyl {N-[3-(hydroxymethyl)phenyl]carbamoyl}ethylphosphonate (1444512-12-2)

Guidance literature:

for 9h; Inert atmosphere; Reflux;

DOI:10.1016/j.bmc.2013.04.076

Reference yield:

3-aminobenzenemethanol (1877-77-6) → diethyl {N-[3-(hydroxymethyl)phenyl]carbamoyl}ethylphosphonate (1444512-12-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 6 h / Inert atmosphere

1.2: 6 h / 20 °C / Inert atmosphere

2.1: 9 h / Inert atmosphere; Reflux

With sodium hydride; In tetrahydrofuran; mineral oil; 2.1: |Michaelis-Arbuzov Synthesis;

DOI:10.1016/j.bmc.2013.04.076

upstream raw materials:

3-aminobenzenemethanol

3-chloro-N-[3-(hydroxymethyl)phenyl]propanamide

triethyl phosphite