(-)-N⁽⁴⁾-(4,4'-dimethoxytrityl)-2',3'-dideoxy-3'-thiacytidine

Base Information

• Chemical Name: (-)-N⁽⁴⁾-(4,4'-dimethoxytrityl)-2',3'-dideoxy-3'-thiacytidine
• CAS No.: 956897-01-1
• Molecular Formula: C₂₉H₂₉N₃O₅S
• Molecular Weight: 531.632
• Mol file: 956897-01-1.mol

Synonyms:(-)-N⁽⁴⁾-(4,4'-dimethoxytrityl)-2',3'-dideoxy-3'-thiacytidine

Chemical Property of (-)-N⁽⁴⁾-(4,4'-dimethoxytrityl)-2',3'-dideoxy-3'-thiacytidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (-)-N⁽⁴⁾-(4,4'-dimethoxytrityl)-2',3'-dideoxy-3'-thiacytidine

There total 1 articles about (-)-N⁽⁴⁾-(4,4'-dimethoxytrityl)-2',3'-dideoxy-3'-thiacytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

lamivudine (134678-17-4) → (-)-N(4)-(4,4'-dimethoxytrityl)-2',3'-dideoxy-3'-thiacytidine (956897-01-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 18 h / 20 °C

2: pyridine / 0 - 20 °C

3: tetrabutyl ammonium fluoride / 3 h

With pyridine; 1H-imidazole; tetrabutyl ammonium fluoride; In N,N-dimethyl-formamide;

DOI:10.1021/jm300492q

Reference yield: 50.0%

(-)-N(4)-(4,4'-dimethoxytrityl)-2',3'-dideoxy-3'-thiacytidine (956897-01-1) + n-tetradecanoic acid (544-63-8) → (-)-N(4)-(4,4'-dimethoxytrityl)-5'-O-(tetradecanoyl)-2',3'-dideoxy-3'-thiacytidine (1373400-25-9)

Guidance literature:

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1021/jm300492q

Reference yield:

1,10-decanedioic acid (111-20-6,26776-29-4) + (-)-N(4)-(4,4'-dimethoxytrityl)-2',3'-dideoxy-3'-thiacytidine (956897-01-1) → C68H72N6O12S2 (1396742-30-5)

Guidance literature:

With 1-hydroxy-7-aza-benzotriazole; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; diisopropyl-carbodiimide; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.bmcl.2012.07.037

upstream raw materials:

lamivudine

Downstream raw materials:

C₅₈H₇₃FN₆O₁₂S

(-)-5'-O-(3-aminopropanoyl)-N⁽⁴⁾-(4,4'-dimethoxytrityl)-2',3'-dideoxy-3'-thiacytidine

(-)-5'-O-(3-(N-Fmoc-aminopropanoyl))-N⁽⁴⁾-(4,4'-dimethoxytrityl)-2',3'-dideoxy-3'-thiacytidine

(-)-5'-O-(12-azidododecanoyl)-N⁽⁴⁾-(4,4'-dimethoxytrityl)-2',3'-dideoxy-3'-thiacytidine