1-{2-(2-tert-butoxycarbonylamino-propionylamino)-3-[3,4-diacetoxy-6-acetoxymethyl-5-(3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-ylsulfanyl]-propionyl}-pyrrolidine-2-carboxylic acid benzyl ester

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Chemical Name:1-{2-(2-tert-butoxycarbonylamino-propionylamino)-3-[3,4-diacetoxy-6-acetoxymethyl-5-(3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-ylsulfanyl]-propionyl}-pyrrolidine-2-carboxylic acid benzyl ester
CAS No.:676602-47-4
Molecular Formula:C₄₉H₆₇N₃O₂₃S
Molecular Weight:1098.14
Hs Code.:

1-{2-(2-<i>tert</i>-butoxycarbonylamino-propionylamino)-3-[3,4-diacetoxy-6-acetoxymethyl-5-(3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-ylsulfanyl]-propionyl}-pyrrolidine-2-carboxylic acid benzyl ester

Synonyms:1-{2-(2-tert-butoxycarbonylamino-propionylamino)-3-[3,4-diacetoxy-6-acetoxymethyl-5-(3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-ylsulfanyl]-propionyl}-pyrrolidine-2-carboxylic acid benzyl ester

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Chemical Property of 1-{2-(2-tert-butoxycarbonylamino-propionylamino)-3-[3,4-diacetoxy-6-acetoxymethyl-5-(3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-ylsulfanyl]-propionyl}-pyrrolidine-2-carboxylic acid benzyl ester

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Technology Process of 1-{2-(2-tert-butoxycarbonylamino-propionylamino)-3-[3,4-diacetoxy-6-acetoxymethyl-5-(3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-ylsulfanyl]-propionyl}-pyrrolidine-2-carboxylic acid benzyl ester

There total 4 articles about 1-{2-(2-tert-butoxycarbonylamino-propionylamino)-3-[3,4-diacetoxy-6-acetoxymethyl-5-(3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-ylsulfanyl]-propionyl}-pyrrolidine-2-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 4753-07-5
2,3,6,2',3',4',6'-hepta-O-acetyl-lactosyl bromide

: 676602-44-1
Boc-Ala-Cys-Pro-OBzl

: 676602-47-4
1-{2-(2-tert-butoxycarbonylamino-propionylamino)-3-[3,4-diacetoxy-6-acetoxymethyl-5-(3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-ylsulfanyl]-propionyl}-pyrrolidine-2-carboxylic acid benzyl ester

Guidance literature:: With sodium carbonate; In N,N-dimethyl-formamide;
DOI:10.1039/b311583f

Reference yield:

: 16652-71-4
benzyl (2S)-2-pyrrolidinecarboxylate hydrochloride

: 676602-47-4
1-{2-(2-tert-butoxycarbonylamino-propionylamino)-3-[3,4-diacetoxy-6-acetoxymethyl-5-(3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-ylsulfanyl]-propionyl}-pyrrolidine-2-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / PyBOP; DIPEA / dimethylformamide

2: aq. TFA / CH₂Cl₂

3: 68 percent / DTT; guanidinium hydrochloride / various solvent(s) / 20 °C / pH 8.0

4: 65 percent / aq. Na₂CO₃ / dimethylformamide

With DL-dithiothreitol; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; guanidine hydrochloride; sodium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/b311583f

Reference yield:

: 676602-43-0
C₃₀H₃₈N₄O₆S₂

: 676602-47-4
1-{2-(2-tert-butoxycarbonylamino-propionylamino)-3-[3,4-diacetoxy-6-acetoxymethyl-5-(3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-ylsulfanyl]-propionyl}-pyrrolidine-2-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 68 percent / DTT; guanidinium hydrochloride / various solvent(s) / 20 °C / pH 8.0

2: 65 percent / aq. Na₂CO₃ / dimethylformamide

With DL-dithiothreitol; guanidine hydrochloride; sodium carbonate; In N,N-dimethyl-formamide;
DOI:10.1039/b311583f