1,5-anhydro-3-<<(benzyloxy)methyl>amino>-3,N,4,O-carbonyl-2,3-dideoxy-6-O-(triisopropylsilyl)-D-ribo-hex-1-enopyranose

Base Information

Chemical Name:1,5-anhydro-3-<<(benzyloxy)methyl>amino>-3,N,4,O-carbonyl-2,3-dideoxy-6-O-(triisopropylsilyl)-D-ribo-hex-1-enopyranose
CAS No.:174290-85-8
Molecular Formula:C₂₄H₃₇NO₅Si
Molecular Weight:447.647
Hs Code.:

Synonyms:1,5-anhydro-3-<<(benzyloxy)methyl>amino>-3,N,4,O-carbonyl-2,3-dideoxy-6-O-(triisopropylsilyl)-D-ribo-hex-1-enopyranose

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Chemical Property of 1,5-anhydro-3-<<(benzyloxy)methyl>amino>-3,N,4,O-carbonyl-2,3-dideoxy-6-O-(triisopropylsilyl)-D-ribo-hex-1-enopyranose

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Technology Process of 1,5-anhydro-3-<<(benzyloxy)methyl>amino>-3,N,4,O-carbonyl-2,3-dideoxy-6-O-(triisopropylsilyl)-D-ribo-hex-1-enopyranose

There total 5 articles about 1,5-anhydro-3-<<(benzyloxy)methyl>amino>-3,N,4,O-carbonyl-2,3-dideoxy-6-O-(triisopropylsilyl)-D-ribo-hex-1-enopyranose which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 137915-37-8
1,2-dideoxy-6-O-triisopropylsilyl-D-arabino-1-hexenopyranose

: 174290-85-8
1,5-anhydro-3-<<(benzyloxy)methyl>amino>-3,N,4,O-carbonyl-2,3-dideoxy-6-O-(triisopropylsilyl)-D-ribo-hex-1-enopyranose

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) NaH / 1.) CH₂Cl₂, 0 deg C, 30 min, 2.) CH₂Cl₂, RT, overnight

2: BF₃*Et₂O / CH₂Cl₂ / 5 h / -78 °C

3: 80 percent / TsOH*H₂O, Py / H₂O / 14 h / 80 °C

4: 97 percent / NaH / CH₂Cl₂ / Ambient temperature

5: 1.) NaH, 2.) tetrabutylammonium iodide / 1.) DMF, 30 min, 2.) DMF, 40 deg C, 10 h

With pyridine; boron trifluoride diethyl etherate; tetra-(n-butyl)ammonium iodide; sodium hydride; toluene-4-sulfonic acid; In dichloromethane; water;
DOI:10.1021/ja952907g

Reference yield:

: 148302-24-3
3-amino-1,5-anhydro-2,3-dideoxy-3,O,4,N-<(trichloromethyl)oxazolino>-6-O-(triisopropylsilyl)-D-ribo-hex-1-enopyranose

: 174290-85-8
1,5-anhydro-3-<<(benzyloxy)methyl>amino>-3,N,4,O-carbonyl-2,3-dideoxy-6-O-(triisopropylsilyl)-D-ribo-hex-1-enopyranose

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / TsOH*H₂O, Py / H₂O / 14 h / 80 °C

2: 97 percent / NaH / CH₂Cl₂ / Ambient temperature

3: 1.) NaH, 2.) tetrabutylammonium iodide / 1.) DMF, 30 min, 2.) DMF, 40 deg C, 10 h

With pyridine; tetra-(n-butyl)ammonium iodide; sodium hydride; toluene-4-sulfonic acid; In dichloromethane; water;
DOI:10.1021/ja952907g

Reference yield:

: 148302-25-4
1,5-anhydro-2,3-dideoxy-3-(trichloroacetamido)-6-O-(triisopropylsilyl)-D-ribo-hex-1-enopyranose

: 174290-85-8
1,5-anhydro-3-<<(benzyloxy)methyl>amino>-3,N,4,O-carbonyl-2,3-dideoxy-6-O-(triisopropylsilyl)-D-ribo-hex-1-enopyranose

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / NaH / CH₂Cl₂ / Ambient temperature

2: 1.) NaH, 2.) tetrabutylammonium iodide / 1.) DMF, 30 min, 2.) DMF, 40 deg C, 10 h

With tetra-(n-butyl)ammonium iodide; sodium hydride; In dichloromethane;
DOI:10.1021/ja952907g