ethyl 2-(4-chloro-2-{[2-methyl-5-(propylsulfonyl)phenyl]ethynyl}phenoxy)butanoate

Base Information

Chemical Name:ethyl 2-(4-chloro-2-{[2-methyl-5-(propylsulfonyl)phenyl]ethynyl}phenoxy)butanoate
CAS No.:1240289-07-9
Molecular Formula:C₂₄H₂₇ClO₅S
Molecular Weight:462.994
Hs Code.:

Synonyms:ethyl 2-(4-chloro-2-{[2-methyl-5-(propylsulfonyl)phenyl]ethynyl}phenoxy)butanoate

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Chemical Property of ethyl 2-(4-chloro-2-{[2-methyl-5-(propylsulfonyl)phenyl]ethynyl}phenoxy)butanoate

Chemical Property:

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Technology Process of ethyl 2-(4-chloro-2-{[2-methyl-5-(propylsulfonyl)phenyl]ethynyl}phenoxy)butanoate

There total 4 articles about ethyl 2-(4-chloro-2-{[2-methyl-5-(propylsulfonyl)phenyl]ethynyl}phenoxy)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1240289-06-8
4-chloro-2-[(2-methyl-5-propylsulfonylphenyl)ethynyl]phenol

: 533-68-6
2-bromobutyric acid ethyl ester

: 1240289-07-9
ethyl 2-(4-chloro-2-{[2-methyl-5-(propylsulfonyl)phenyl]ethynyl}phenoxy)butanoate

Guidance literature:: With potassium carbonate; In 1,2-dimethoxyethane; for 18h; Reflux;

Reference yield:

: 1240289-05-7
3-{[5-chloro-2-(methoxymethoxy)phenyl]ethynyl}-4-methylphenyl propyl sulfone

: 1240289-07-9
ethyl 2-(4-chloro-2-{[2-methyl-5-(propylsulfonyl)phenyl]ethynyl}phenoxy)butanoate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane / 7 h / 20 °C

2: potassium carbonate / 1,2-dimethoxyethane / 18 h / Reflux

With hydrogenchloride; potassium carbonate; In 1,4-dioxane; 1,2-dimethoxyethane;
DOI:10.1021/jm200866y

Reference yield:

: 695-96-5
2-bromo-4-chlorophenol

: 1240289-07-9
ethyl 2-(4-chloro-2-{[2-methyl-5-(propylsulfonyl)phenyl]ethynyl}phenoxy)butanoate

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C

2: copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride; triphenylphosphine / triethylamine / 80 °C / Inert atmosphere

3: hydrogenchloride / 1,4-dioxane / 7 h / 20 °C

4: potassium carbonate / 1,2-dimethoxyethane / 18 h / Reflux

With hydrogenchloride; copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; triethylamine; 2: Sonogashira coupling;
DOI:10.1021/jm200866y