5H-Benzo[g]-1,3-benzodioxolo[6,5,4-de]quinoline, 6,7,7a,8-tetrahydro-10-methoxy-7-methyl-

Base Information

• Chemical Name: 5H-Benzo[g]-1,3-benzodioxolo[6,5,4-de]quinoline, 6,7,7a,8-tetrahydro-10-methoxy-7-methyl-
• CAS No.: 28360-52-3
• Molecular Formula: C₁₉H₁₉NO₃
• Molecular Weight: 309.365
• NSC Number: 383229
• DSSTox Substance ID: DTXSID201123077
• Wikidata: Q105023038
• ChEMBL ID: CHEMBL600966
• Mol file: 28360-52-3.mol

Synonyms:NSC383229;GNF-Pf-4066;5H-Benzo[g]-1,3-benzodioxolo[6,5,4-de]quinoline, 6,7,7a,8-tetrahydro-10-methoxy-7-methyl-;CHEMBL600966;DTXSID201123077;NSC-383229;NCI60_003672;28360-52-3

Chemical Property of 5H-Benzo[g]-1,3-benzodioxolo[6,5,4-de]quinoline, 6,7,7a,8-tetrahydro-10-methoxy-7-methyl-

Chemical Property:

• XLogP3: 3.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 309.13649347
• Heavy Atom Count: 23
• Complexity: 458

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1CCC2=CC3=C(C4=C2C1CC5=C4C=CC(=C5)OC)OCO3

Technology Process of 5H-Benzo[g]-1,3-benzodioxolo[6,5,4-de]quinoline, 6,7,7a,8-tetrahydro-10-methoxy-7-methyl-

There total 1 articles about 5H-Benzo[g]-1,3-benzodioxolo[6,5,4-de]quinoline, 6,7,7a,8-tetrahydro-10-methoxy-7-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methoxy-2-(6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-ylmethyl)-aniline (28200-70-6) → N-methyl-6,7-methylenedioxy-1,2,3,4-tetrahydroisoquinoline (494-55-3) + 5-methoxy-1H-indazole (94444-96-9) + 10-methoxy-7-methyl-6,7,7a,8-tetrahydro-5H-benzo[g][1,3]dioxolo[4',5':4,5]benzo[1,2,3-de]quinoline (28360-52-3)

Guidance literature:

Erwaermen der Reaktionsloesung bis auf 90grad und anschliessenden Erwaermen mit Zink-Pulver und konz. wss. HCl;

DOI:10.1021/ja01235a021

Reference yield:

10-methoxy-7-methyl-6,7,7a,8-tetrahydro-5H-benzo[g][1,3]dioxolo[4',5':4,5]benzo[1,2,3-de]quinoline (28360-52-3) → lanuginosine (23740-25-2)

Guidance literature:

With chromium(VI) oxide; In pyridine;

upstream raw materials:

4-methoxy-2-(6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-ylmethyl)-aniline

Downstream raw materials:

lanuginosine