tert-butyl N-[(1S)-1-(tert-butoxycarbonyl)-3-methylbutyl]-L-alanyl-(4S)-4-{[(3R)-3-[(tert-butoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoyl]amino}-L-prolinate

Base Information

Chemical Name:tert-butyl N-[(1S)-1-(tert-butoxycarbonyl)-3-methylbutyl]-L-alanyl-(4S)-4-{[(3R)-3-[(tert-butoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoyl]amino}-L-prolinate
CAS No.:1321615-14-8
Molecular Formula:C₃₇H₅₇F₃N₄O₈
Molecular Weight:742.877
Hs Code.:

tert-butyl N-[(1S)-1-(tert-butoxycarbonyl)-3-methylbutyl]-L-alanyl-(4S)-4-{[(3R)-3-[(tert-butoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoyl]amino}-L-prolinate

Synonyms:tert-butyl N-[(1S)-1-(tert-butoxycarbonyl)-3-methylbutyl]-L-alanyl-(4S)-4-{[(3R)-3-[(tert-butoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoyl]amino}-L-prolinate

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Chemical Property of tert-butyl N-[(1S)-1-(tert-butoxycarbonyl)-3-methylbutyl]-L-alanyl-(4S)-4-{[(3R)-3-[(tert-butoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoyl]amino}-L-prolinate

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Technology Process of tert-butyl N-[(1S)-1-(tert-butoxycarbonyl)-3-methylbutyl]-L-alanyl-(4S)-4-{[(3R)-3-[(tert-butoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoyl]amino}-L-prolinate

There total 9 articles about tert-butyl N-[(1S)-1-(tert-butoxycarbonyl)-3-methylbutyl]-L-alanyl-(4S)-4-{[(3R)-3-[(tert-butoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoyl]amino}-L-prolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1321615-13-7
tert-butyl (4S)-1-((2R)-bromopropanoyl)-4-{[(3R)-3-[(tert-butoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoyl]amino}-L-prolinate

: 2748-02-9,13081-32-8
L-leucine tert-butyl ester hydrochloride

: 1321615-14-8
tert-butyl N-[(1S)-1-(tert-butoxycarbonyl)-3-methylbutyl]-L-alanyl-(4S)-4-{[(3R)-3-[(tert-butoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoyl]amino}-L-prolinate

Guidance literature:: With potassium carbonate; potassium iodide; In acetonitrile; at 60 - 65 ℃; for 12h; Inert atmosphere;

Reference yield:

: 51-35-4,30724-02-8
4R-4-hydroxyproline

: 1321615-14-8
tert-butyl N-[(1S)-1-(tert-butoxycarbonyl)-3-methylbutyl]-L-alanyl-(4S)-4-{[(3R)-3-[(tert-butoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoyl]amino}-L-prolinate

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium hydrogencarbonate / 1,4-dioxane; water / 12.25 h / 25 °C / Inert atmosphere; Cooling

2.1: potassium carbonate / benzyltrimethylammonium chloride / N,N-dimethyl acetamide / 12 h / 50 - 55 °C / Industry scale

3.1: triethylamine / dichloromethane / 12.5 h / 0 - 25 °C

4.1: sodium azide / N,N-dimethyl-formamide / 5 h / 50 - 60 °C

5.1: triphenylphosphine / tetrahydrofuran / 25 °C

5.2: 3 h / Reflux

6.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 12.25 h / 0 - 25 °C

7.1: ammonium formate / palladium 10% on activated carbon / methanol / 2 h / 80 °C

8.1: dicyclohexyl-carbodiimide / dichloromethane / 18 h / 25 °C / Inert atmosphere

9.1: potassium carbonate / potassium iodide / acetonitrile / 12 h / 60 - 65 °C / Inert atmosphere

With sodium azide; ammonium formate; sodium hydrogencarbonate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; dicyclohexyl-carbodiimide; triphenylphosphine; palladium 10% on activated carbon; benzyltrimethylammonium chloride; potassium iodide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 13504-85-3
(2S,4R)-1-(benzyloxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid

: 1321615-14-8
tert-butyl N-[(1S)-1-(tert-butoxycarbonyl)-3-methylbutyl]-L-alanyl-(4S)-4-{[(3R)-3-[(tert-butoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoyl]amino}-L-prolinate

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium carbonate / benzyltrimethylammonium chloride / N,N-dimethyl acetamide / 12 h / 50 - 55 °C / Industry scale

2.1: triethylamine / dichloromethane / 12.5 h / 0 - 25 °C

3.1: sodium azide / N,N-dimethyl-formamide / 5 h / 50 - 60 °C

4.1: triphenylphosphine / tetrahydrofuran / 25 °C

4.2: 3 h / Reflux

5.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 12.25 h / 0 - 25 °C

6.1: ammonium formate / palladium 10% on activated carbon / methanol / 2 h / 80 °C

7.1: dicyclohexyl-carbodiimide / dichloromethane / 18 h / 25 °C / Inert atmosphere

8.1: potassium carbonate / potassium iodide / acetonitrile / 12 h / 60 - 65 °C / Inert atmosphere

With sodium azide; ammonium formate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; dicyclohexyl-carbodiimide; triphenylphosphine; palladium 10% on activated carbon; benzyltrimethylammonium chloride; potassium iodide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide; acetonitrile;