methyl (2S)-3-(2-phenyl-1H-indol-3-yl)-2-(trifluoroacetamido)-propanoate

Base Information

Chemical Name:methyl (2S)-3-(2-phenyl-1H-indol-3-yl)-2-(trifluoroacetamido)-propanoate
CAS No.:1363260-61-0
Molecular Formula:C₂₀H₁₇F₃N₂O₃
Molecular Weight:390.362
Hs Code.:

Synonyms:methyl (2S)-3-(2-phenyl-1H-indol-3-yl)-2-(trifluoroacetamido)-propanoate

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Chemical Property of methyl (2S)-3-(2-phenyl-1H-indol-3-yl)-2-(trifluoroacetamido)-propanoate

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Technology Process of methyl (2S)-3-(2-phenyl-1H-indol-3-yl)-2-(trifluoroacetamido)-propanoate

There total 4 articles about methyl (2S)-3-(2-phenyl-1H-indol-3-yl)-2-(trifluoroacetamido)-propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1604-49-5
methyl (2S)-3-(1H-indol-3-yl)-2-(trifluoroacetamido)propanoate

: 144930-50-7
mesityl(phenyl)iodonium triflouromethanesulfonate

: 1363260-61-0
methyl (2S)-3-(2-phenyl-1H-indol-3-yl)-2-(trifluoroacetamido)-propanoate

: methyl (2S)-3-(2-phenyl-1H-indol-3-yl)-2-(trifluoroacetamido)-propanoate

Guidance literature:: With palladium diacetate; In ethyl acetate; at 25 ℃; for 16h;
DOI:10.1039/c5ob01174d

Reference yield:

: 948-65-2
2-phenyl-indole

: 58137-35-2
methyl 2-(trifluoroacetamido)acrylate

: (R)-N(α)-trifluoroacetyl-2-phenyltryptophan methyl ester

: 1363260-61-0
methyl (2S)-3-(2-phenyl-1H-indol-3-yl)-2-(trifluoroacetamido)-propanoate

Guidance literature:: With (R)-1,1'-Bi-2-naphthol; tin(IV) chloride; In dichloromethane; at 20 ℃; for 2h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1021/ja209390d

Reference yield:

: 108-67-8
1,3,5-trimethyl-benzene

: 1363260-61-0
methyl (2S)-3-(2-phenyl-1H-indol-3-yl)-2-(trifluoroacetamido)-propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane / 2 h / 0 - 20 °C

2: palladium diacetate / ethyl acetate / 16 h / 25 °C

With palladium diacetate; In dichloromethane; ethyl acetate;
DOI:10.1039/c5ob01174d