(S)-1-((2-methoxyphenyl)(methyl)carbamoyl)pyrrolidine-2-carboxylic acid

Base Information

Chemical Name:(S)-1-((2-methoxyphenyl)(methyl)carbamoyl)pyrrolidine-2-carboxylic acid
CAS No.:1462366-72-8
Molecular Formula:C₁₄H₁₈N₂O₄
Molecular Weight:278.308
Hs Code.:

Synonyms:(S)-1-((2-methoxyphenyl)(methyl)carbamoyl)pyrrolidine-2-carboxylic acid

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Chemical Property of (S)-1-((2-methoxyphenyl)(methyl)carbamoyl)pyrrolidine-2-carboxylic acid

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Technology Process of (S)-1-((2-methoxyphenyl)(methyl)carbamoyl)pyrrolidine-2-carboxylic acid

There total 4 articles about (S)-1-((2-methoxyphenyl)(methyl)carbamoyl)pyrrolidine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1462366-71-7
benzyl (S)-1-((2-methoxyphenyl)(methyl)carbamoyl)pyrrolidine-2-carboxylate

: 1462366-72-8
(S)-1-((2-methoxyphenyl)(methyl)carbamoyl)pyrrolidine-2-carboxylic acid

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 20h; Inert atmosphere;
DOI:10.1039/c3cc46193a

Reference yield:

: 55240-00-1
N-(2-methoxyphenyl)-N-methylcarbamoyl chloride

: 1462366-72-8
(S)-1-((2-methoxyphenyl)(methyl)carbamoyl)pyrrolidine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / 1,2-dimethoxyethane / 0.17 h / Inert atmosphere

1.2: 20 h / Inert atmosphere; Reflux

2.1: palladium 10% on activated carbon; hydrogen / methanol / 20 h / 20 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; triethylamine; In methanol; 1,2-dimethoxyethane;
DOI:10.1039/c3cc46193a

Reference yield:

: 10541-78-3
2-methoxy-N-methylaniline

: 1462366-72-8
(S)-1-((2-methoxyphenyl)(methyl)carbamoyl)pyrrolidine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / dichloromethane / -78 °C / Inert atmosphere

2.1: triethylamine / 1,2-dimethoxyethane / 0.17 h / Inert atmosphere

2.2: 20 h / Inert atmosphere; Reflux

3.1: palladium 10% on activated carbon; hydrogen / methanol / 20 h / 20 °C / Inert atmosphere

With pyridine; palladium 10% on activated carbon; hydrogen; triethylamine; In methanol; 1,2-dimethoxyethane; dichloromethane;
DOI:10.1039/c3cc46193a