[1-(4-{[2-(4-chlorophenyl)ethyl]sulfamoyl} benzyl)isoquinolin-4-yl]acetic acid

Base Information

Chemical Name:[1-(4-{[2-(4-chlorophenyl)ethyl]sulfamoyl} benzyl)isoquinolin-4-yl]acetic acid
CAS No.:1233248-28-6
Molecular Formula:C₂₆H₂₃ClN₂O₄S
Molecular Weight:494.999
Hs Code.:

Synonyms:[1-(4-{[2-(4-chlorophenyl)ethyl]sulfamoyl} benzyl)isoquinolin-4-yl]acetic acid

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Chemical Property of [1-(4-{[2-(4-chlorophenyl)ethyl]sulfamoyl} benzyl)isoquinolin-4-yl]acetic acid

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Technology Process of [1-(4-{[2-(4-chlorophenyl)ethyl]sulfamoyl} benzyl)isoquinolin-4-yl]acetic acid

There total 6 articles about [1-(4-{[2-(4-chlorophenyl)ethyl]sulfamoyl} benzyl)isoquinolin-4-yl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1233249-88-1
1-(4-{[2-(4-chlorophenyl)ethyl]sulfamoyl}benzyl)isoquinoline-4-carboxylic acid

: 18107-18-1
diazomethyl-trimethyl-silane

: 1233248-28-6
[1-(4-{[2-(4-chlorophenyl)ethyl]sulfamoyl} benzyl)isoquinolin-4-yl]acetic acid

Guidance literature:: 1-(4-{[2-(4-chlorophenyl)ethyl]sulfamoyl}benzyl)isoquinoline-4-carboxylic acid; With oxalyl dichloride; In chloroform; N,N-dimethyl-formamide; at 20 ℃; for 1h; Cooling with ice;

diazomethyl-trimethyl-silane; In tetrahydrofuran; acetonitrile; for 1h; Cooling with ice;

With silver(I) acetate; In 1,4-dioxane; water; at 60 ℃; for 0.5h;

Reference yield:

: 156-41-2
4-chlorophenylethylamine

: 1233248-28-6
[1-(4-{[2-(4-chlorophenyl)ethyl]sulfamoyl} benzyl)isoquinolin-4-yl]acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / tetrahydrofuran / 1 h / 20 °C

2.1: 0.5 h / 60 °C

3.1: sodium hexamethyldisilazane / tetrahydrofuran / 3 h / -30 - 50 °C

3.2: 2 h / 50 °C

4.1: sodium hydroxide; water / tetrahydrofuran / 3 h / 20 °C

5.1: oxalyl dichloride / N,N-dimethyl-formamide; chloroform / 1 h / 20 °C / Cooling with ice

5.2: 1 h / Cooling with ice

5.3: 0.5 h / 60 °C

With oxalyl dichloride; water; sodium hexamethyldisilazane; triethylamine; sodium hydroxide; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide;

Reference yield:

: 1233249-86-9
tributyl(4-{[2-(4-chlorophenyl)ethyl]sulfamoyl}benzyl)phosphonium bromide

: 1233248-28-6
[1-(4-{[2-(4-chlorophenyl)ethyl]sulfamoyl} benzyl)isoquinolin-4-yl]acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 3 h / -30 - 50 °C

1.2: 2 h / 50 °C

2.1: sodium hydroxide; water / tetrahydrofuran / 3 h / 20 °C

3.1: oxalyl dichloride / N,N-dimethyl-formamide; chloroform / 1 h / 20 °C / Cooling with ice

3.2: 1 h / Cooling with ice

3.3: 0.5 h / 60 °C

With oxalyl dichloride; water; sodium hexamethyldisilazane; sodium hydroxide; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide;