syn-4-phenyltetrahydro-1aH-oxireno[2,3-f]isoindole-3,5(4H,5aH)-dione

Base Information

• Chemical Name: syn-4-phenyltetrahydro-1aH-oxireno[2,3-f]isoindole-3,5(4H,5aH)-dione
• CAS No.: 19626-85-8
• Molecular Formula: C₁₄H₁₃NO₃
• Molecular Weight: 243.262
• Mol file: 19626-85-8.mol

Synonyms:syn-4-phenyltetrahydro-1aH-oxireno[2,3-f]isoindole-3,5(4H,5aH)-dione

Chemical Property of syn-4-phenyltetrahydro-1aH-oxireno[2,3-f]isoindole-3,5(4H,5aH)-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of syn-4-phenyltetrahydro-1aH-oxireno[2,3-f]isoindole-3,5(4H,5aH)-dione

There total 4 articles about syn-4-phenyltetrahydro-1aH-oxireno[2,3-f]isoindole-3,5(4H,5aH)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-phenyl-3a,4,7,7a-tetrahydro-1H-isoindole-1,3(2H)-dione (2015-58-9) → syn-4-phenyltetrahydro-1aH-oxireno[2,3-f]isoindole-3,5(4H,5aH)-dione (19626-85-8) + (anti)-4-phenyltetrahydro-1aH-oxireno[f]isoindole-3,5(2H,4H)-dione (1301212-79-2)

Guidance literature:

With sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 6h;

DOI:10.1055/s-0030-1258466

Reference yield:

aniline (62-53-3) → syn-4-phenyltetrahydro-1aH-oxireno[2,3-f]isoindole-3,5(4H,5aH)-dione (19626-85-8) + (anti)-4-phenyltetrahydro-1aH-oxireno[f]isoindole-3,5(2H,4H)-dione (1301212-79-2)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / toluene / 36 h / Reflux

2: sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid / dichloromethane / 6 h / 20 °C

With sodium hydrogencarbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; toluene;

DOI:10.1055/s-0030-1258466

Reference yield:

1,2,3,6-Tetrahydrophthalic anhydride (85-43-8) → syn-4-phenyltetrahydro-1aH-oxireno[2,3-f]isoindole-3,5(4H,5aH)-dione (19626-85-8) + (anti)-4-phenyltetrahydro-1aH-oxireno[f]isoindole-3,5(2H,4H)-dione (1301212-79-2)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / toluene / 36 h / Reflux

2: sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid / dichloromethane / 6 h / 20 °C

With sodium hydrogencarbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; toluene;

DOI:10.1055/s-0030-1258466

upstream raw materials:

cis-2-phenyl-3a,4,7,7a-tetrahydro-1H-isoindole-1,3(2H)-dione

2-phenyl-3a,4,7,7a-tetrahydro-1H-isoindole-1,3(2H)-dione

aniline

1,2,3,6-Tetrahydrophthalic anhydride