(S)-1-[(tert-butyldimethylsilyl)oxy]-3-(diphenylphosphinoyl)-1-phenylpropan-2-one

Base Information

Chemical Name:(S)-1-[(tert-butyldimethylsilyl)oxy]-3-(diphenylphosphinoyl)-1-phenylpropan-2-one
CAS No.:1010708-42-5
Molecular Formula:C₂₇H₃₃O₃PSi
Molecular Weight:464.616
Hs Code.:

Synonyms:(S)-1-[(tert-butyldimethylsilyl)oxy]-3-(diphenylphosphinoyl)-1-phenylpropan-2-one

Suppliers and Price of (S)-1-[(tert-butyldimethylsilyl)oxy]-3-(diphenylphosphinoyl)-1-phenylpropan-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-1-[(tert-butyldimethylsilyl)oxy]-3-(diphenylphosphinoyl)-1-phenylpropan-2-one

Chemical Property:

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Technology Process of (S)-1-[(tert-butyldimethylsilyl)oxy]-3-(diphenylphosphinoyl)-1-phenylpropan-2-one

There total 1 articles about (S)-1-[(tert-butyldimethylsilyl)oxy]-3-(diphenylphosphinoyl)-1-phenylpropan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 133187-21-0
Methyl (S)-(+)-α-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-α-phenylacetate

: 2129-89-7
diphenyl(methyl)phosphine oxide

: 1010708-42-5
(S)-1-[(tert-butyldimethylsilyl)oxy]-3-(diphenylphosphinoyl)-1-phenylpropan-2-one

Guidance literature:: diphenyl(methyl)phosphine oxide; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

Methyl (S)-(+)-α-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-α-phenylacetate; In tetrahydrofuran; hexane; at -78 ℃; for 12h; Further stages.;
DOI:10.1016/j.tetasy.2007.12.016

Reference yield: 93.0%

: 1010708-42-5
(S)-1-[(tert-butyldimethylsilyl)oxy]-3-(diphenylphosphinoyl)-1-phenylpropan-2-one

: 1010708-43-6
(1S,2R)-1-[(tert-butyldimethylsilyl)oxy]-3-(diphenylphosphinoyl)-1-phenylpropan-2-ol

: 1010708-44-7
(1S,2S)-1-[(tert-butyldimethylsilyl)oxy]-3-(diphenylphosphinoyl)-1-phenylpropan-2-ol

Guidance literature:: With sodium tetrahydroborate; In methanol; at -78 ℃; for 6h;
DOI:10.1016/j.tetasy.2007.12.016

Reference yield:

: 1010708-42-5
(S)-1-[(tert-butyldimethylsilyl)oxy]-3-(diphenylphosphinoyl)-1-phenylpropan-2-one

: 1010708-45-8
(1S,2S)-3-(diphenylphosphinoyl)-1-phenylpropane-1,2-diol

: 165611-42-7
(1S,2R)-3-(diphenylphosphinoyl)-1-phenylpropane-1,2-diol

Guidance literature:: With diisobutylaluminium hydride; In tetrahydrofuran; at -78 ℃; Title compound not separated from byproducts.;
DOI:10.1016/j.tetasy.2007.12.016