5-piperidin-1-yl-pentanoic acid [3-(4-trifluoromethylphenyl)-1H-pyrazol-5-yl]amide

Base Information

Chemical Name:5-piperidin-1-yl-pentanoic acid [3-(4-trifluoromethylphenyl)-1H-pyrazol-5-yl]amide
CAS No.:1040719-01-4
Molecular Formula:C₂₀H₂₅F₃N₄O
Molecular Weight:394.44
Hs Code.:

Synonyms:5-piperidin-1-yl-pentanoic acid [3-(4-trifluoromethylphenyl)-1H-pyrazol-5-yl]amide

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Chemical Property of 5-piperidin-1-yl-pentanoic acid [3-(4-trifluoromethylphenyl)-1H-pyrazol-5-yl]amide

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Technology Process of 5-piperidin-1-yl-pentanoic acid [3-(4-trifluoromethylphenyl)-1H-pyrazol-5-yl]amide

There total 5 articles about 5-piperidin-1-yl-pentanoic acid [3-(4-trifluoromethylphenyl)-1H-pyrazol-5-yl]amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2967-66-0
methyl 4-(trifluoromethyl)benzoate

: 1040719-01-4
5-piperidin-1-yl-pentanoic acid [3-(4-trifluoromethylphenyl)-1H-pyrazol-5-yl]amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / hexane; toluene / 0.33 h / -78 °C / Inert atmosphere

1.2: 0.33 h / 20 °C / Inert atmosphere

2.1: hydrazine hydrate / ethanol / 18 h / Reflux

3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 2.5 h / -10 °C / Inert atmosphere

4.1: sodium iodide / N,N-dimethyl-formamide / 60 °C

With n-butyllithium; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; sodium iodide; In ethanol; hexane; N,N-dimethyl acetamide; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm300247y

Reference yield:

: 110-89-4
piperidine

: 1374979-28-8
C₁₅H₁₅BrF₃N₃O

: 1040719-01-4
5-piperidin-1-yl-pentanoic acid [3-(4-trifluoromethylphenyl)-1H-pyrazol-5-yl]amide

Guidance literature:: With sodium iodide; In N,N-dimethyl-formamide; at 60 ℃;
DOI:10.1021/jm300247y

Reference yield:

: 130599-34-7
5-(4-(trifluoromethyl)phenyl)-2H-pyrazol-3-ylamine

: 1040719-01-4
5-piperidin-1-yl-pentanoic acid [3-(4-trifluoromethylphenyl)-1H-pyrazol-5-yl]amide

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 2.5 h / -10 °C / Inert atmosphere

2: sodium iodide / N,N-dimethyl-formamide / 60 °C

With N-ethyl-N,N-diisopropylamine; sodium iodide; In N,N-dimethyl acetamide; N,N-dimethyl-formamide;
DOI:10.1021/jm300247y