6-(1,1-dioxo-hexahydro-1λ6-thiopyran-4-yl)-5-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-naphthalen-2-ol

Base Information

Chemical Name:6-(1,1-dioxo-hexahydro-1λ6-thiopyran-4-yl)-5-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-naphthalen-2-ol
CAS No.:862130-04-9
Molecular Formula:C₂₈H₃₃NO₅S
Molecular Weight:495.64
Hs Code.:

Synonyms:6-(1,1-dioxo-hexahydro-1λ6-thiopyran-4-yl)-5-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-naphthalen-2-ol

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Chemical Property of 6-(1,1-dioxo-hexahydro-1λ6-thiopyran-4-yl)-5-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-naphthalen-2-ol

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Technology Process of 6-(1,1-dioxo-hexahydro-1λ6-thiopyran-4-yl)-5-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-naphthalen-2-ol

There total 14 articles about 6-(1,1-dioxo-hexahydro-1λ6-thiopyran-4-yl)-5-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-naphthalen-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6-(1,1-dioxo-1,2,3,6-tetrahydro-1λ6-thiopyran-4-yl)-5-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-naphthalen-2-ol hydrochloride

: 862130-04-9
6-(1,1-dioxo-hexahydro-1λ6-thiopyran-4-yl)-5-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-naphthalen-2-ol

Guidance literature:: With hydrogen; palladium; In tetrahydrofuran; methanol; at 60 ℃; for 12h; under 2844.39 Torr;

Reference yield:

: 862129-85-9
6-(1,1-dioxo-1,2,3,6-tetrahydro-1λ6-thiopyran-4-yl)-5-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-naphthalen-2-ol

: 862130-04-9
6-(1,1-dioxo-hexahydro-1λ6-thiopyran-4-yl)-5-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-naphthalen-2-ol

Guidance literature:: With hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol;
DOI:10.1016/j.bmcl.2007.04.044

Reference yield:

: 648904-47-6
2-(benzyloxy)-1-bromo-6-methoxynaphthalene

: 862130-04-9
6-(1,1-dioxo-hexahydro-1λ6-thiopyran-4-yl)-5-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-naphthalen-2-ol

Guidance literature:: Multi-step reaction with 7 steps

1: 30 percent / copper triflate

2: NH₄HCO₂ / Pd(OH)2

3: PCy₃; CsF / Pd(OAc)2

4: oxone / methanol

5: BBr₃; isobutene / CH₂Cl₂

6: H₂ / Pd/C / tetrahydrofuran; ethanol

With Oxone; hydrogen; ammonium formate; boron tribromide; copper(I) triflate; cesium fluoride; isobutene; tricyclohexylphosphine; palladium diacetate; palladium dihydroxide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; 1: Ullman coupling / 4: Suzuki coupling;
DOI:10.1016/j.bmcl.2007.04.044