Technology Process of [10,11-13C2]-1,3,3-trimethyl-2-((1E,3E)-3-methylhexa-1,3-dien-5-ynyl)cyclohex-1-ene
There total 3 articles about [10,11-13C2]-1,3,3-trimethyl-2-((1E,3E)-3-methylhexa-1,3-dien-5-ynyl)cyclohex-1-ene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
diazomethyl-trimethyl-silane;
With
lithium diisopropyl amide;
In
tetrahydrofuran; diethyl ether;
at -78 ℃;
for 0.75h;
[10,11-13C2]-(2E,4E)-3-methyl-5-(2,6,6-trimethylcyclohex-1-enyl)penta-2,4-dienal;
In
tetrahydrofuran; diethyl ether;
at -78 - 20 ℃;
DOI:10.1016/j.tet.2011.07.092
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: lithium aluminium tetrahydride / diethyl ether / -78 - 20 °C
2.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 0.5 h / 20 °C / Molecular sieve
3.1: lithium diisopropyl amide / tetrahydrofuran; diethyl ether / 0.75 h / -78 °C
3.2: -78 - 20 °C
With
lithium aluminium tetrahydride; tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide; lithium diisopropyl amide;
In
tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1016/j.tet.2011.07.092
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 0.5 h / 20 °C / Molecular sieve
2.1: lithium diisopropyl amide / tetrahydrofuran; diethyl ether / 0.75 h / -78 °C
2.2: -78 - 20 °C
With
tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide; lithium diisopropyl amide;
In
tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1016/j.tet.2011.07.092