(R)-Methoxy-phenyl-acetic acid (1S,2S)-3-{2-[(2S,3S,4R)-6-benzyloxy-2,4-bis-(tert-butyl-dimethyl-silanyloxy)-3-methyl-hexyl]-[1,3]dithian-2-yl}-2-(4-methoxy-benzyloxy)-3-methyl-1-vinyl-butyl ester

Base Information

Chemical Name:(R)-Methoxy-phenyl-acetic acid (1S,2S)-3-{2-[(2S,3S,4R)-6-benzyloxy-2,4-bis-(tert-butyl-dimethyl-silanyloxy)-3-methyl-hexyl]-[1,3]dithian-2-yl}-2-(4-methoxy-benzyloxy)-3-methyl-1-vinyl-butyl ester
CAS No.:137765-34-5
Molecular Formula:C₅₄H₈₄O₈S₂Si₂
Molecular Weight:981.559
Hs Code.:

(R)-Methoxy-phenyl-acetic acid (1S,2S)-3-{2-[(2S,3S,4R)-6-benzyloxy-2,4-bis-(tert-butyl-dimethyl-silanyloxy)-3-methyl-hexyl]-[1,3]dithian-2-yl}-2-(4-methoxy-benzyloxy)-3-methyl-1-vinyl-butyl ester

Synonyms:(R)-Methoxy-phenyl-acetic acid (1S,2S)-3-{2-[(2S,3S,4R)-6-benzyloxy-2,4-bis-(tert-butyl-dimethyl-silanyloxy)-3-methyl-hexyl]-[1,3]dithian-2-yl}-2-(4-methoxy-benzyloxy)-3-methyl-1-vinyl-butyl ester

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Chemical Property of (R)-Methoxy-phenyl-acetic acid (1S,2S)-3-{2-[(2S,3S,4R)-6-benzyloxy-2,4-bis-(tert-butyl-dimethyl-silanyloxy)-3-methyl-hexyl]-[1,3]dithian-2-yl}-2-(4-methoxy-benzyloxy)-3-methyl-1-vinyl-butyl ester

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Technology Process of (R)-Methoxy-phenyl-acetic acid (1S,2S)-3-{2-[(2S,3S,4R)-6-benzyloxy-2,4-bis-(tert-butyl-dimethyl-silanyloxy)-3-methyl-hexyl]-[1,3]dithian-2-yl}-2-(4-methoxy-benzyloxy)-3-methyl-1-vinyl-butyl ester

There total 12 articles about (R)-Methoxy-phenyl-acetic acid (1S,2S)-3-{2-[(2S,3S,4R)-6-benzyloxy-2,4-bis-(tert-butyl-dimethyl-silanyloxy)-3-methyl-hexyl]-[1,3]dithian-2-yl}-2-(4-methoxy-benzyloxy)-3-methyl-1-vinyl-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 3966-32-3
(R)-methoxyphenylacetic acid

: 137664-68-7
(3S,4S)-5-{2-[(2S,3S,4R)-6-Benzyloxy-2,4-bis-(tert-butyl-dimethyl-silanyloxy)-3-methyl-hexyl]-[1,3]dithian-2-yl}-4-(4-methoxy-benzyloxy)-5-methyl-hex-1-en-3-ol

: 137765-34-5
(R)-Methoxy-phenyl-acetic acid (1S,2S)-3-{2-[(2S,3S,4R)-6-benzyloxy-2,4-bis-(tert-butyl-dimethyl-silanyloxy)-3-methyl-hexyl]-[1,3]dithian-2-yl}-2-(4-methoxy-benzyloxy)-3-methyl-1-vinyl-butyl ester

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane;
DOI:10.1016/S0040-4039(00)93479-8

Reference yield:

: 137664-76-7
(S)-3-[1,3]Dithian-2-yl-3-methyl-butane-1,2-diol

: 137765-34-5
(R)-Methoxy-phenyl-acetic acid (1S,2S)-3-{2-[(2S,3S,4R)-6-benzyloxy-2,4-bis-(tert-butyl-dimethyl-silanyloxy)-3-methyl-hexyl]-[1,3]dithian-2-yl}-2-(4-methoxy-benzyloxy)-3-methyl-1-vinyl-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: 85 percent / TsOH / dimethylformamide

2.1: n-BuLi; HMPA / tetrahydrofuran

2.2: 81 percent / DMPU / tetrahydrofuran / -20 °C

3.1: 95 percent / 2,6-lutidine

4.1: 94 percent / DIBAL / CH₂Cl₂ / -78 - 0 °C

5.1: 87 percent / SO₃*pyridine; DMSO; Et₃N / CH₂Cl₂

6.1: tetrahydrofuran / -78 °C

7.1: DCC; DMAP / CH₂Cl₂

With 2,6-dimethylpyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; n-butyllithium; pyridine-SO₃ complex; diisobutylaluminium hydride; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 1.1: acetalization / 2.1: Metallation / 2.2: Addition / 3.1: silylation / 4.1: reductive cleavage / 5.1: Oxidation / 6.1: Grignard reaction / 7.1: Esterification;
DOI:10.1021/ja992134m

Reference yield:

: 137664-71-2
2-((S)-2,2-Diethyl-[1,3]dioxolan-4-yl)-2-methyl-propan-1-ol

: 137765-34-5
(R)-Methoxy-phenyl-acetic acid (1S,2S)-3-{2-[(2S,3S,4R)-6-benzyloxy-2,4-bis-(tert-butyl-dimethyl-silanyloxy)-3-methyl-hexyl]-[1,3]dithian-2-yl}-2-(4-methoxy-benzyloxy)-3-methyl-1-vinyl-butyl ester

Guidance literature:: Multi-step reaction with 9 steps

1.1: DMSO; (COCl)2; Et₃N / CH₂Cl₂ / -78 °C

2.1: BF₃*Et₂O / CH₂Cl₂ / 0 °C

3.1: 85 percent / TsOH / dimethylformamide

4.1: n-BuLi; HMPA / tetrahydrofuran

4.2: 81 percent / DMPU / tetrahydrofuran / -20 °C

5.1: 95 percent / 2,6-lutidine

6.1: 94 percent / DIBAL / CH₂Cl₂ / -78 - 0 °C

7.1: 87 percent / SO₃*pyridine; DMSO; Et₃N / CH₂Cl₂

8.1: tetrahydrofuran / -78 °C

9.1: DCC; DMAP / CH₂Cl₂

With 2,6-dimethylpyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; n-butyllithium; oxalyl dichloride; pyridine-SO₃ complex; boron trifluoride diethyl etherate; diisobutylaluminium hydride; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 1.1: Oxidation / 2.1: thioacetalization; deacetalization / 3.1: acetalization / 4.1: Metallation / 4.2: Addition / 5.1: silylation / 6.1: reductive cleavage / 7.1: Oxidation / 8.1: Grignard reaction / 9.1: Esterification;
DOI:10.1021/ja992134m