1-[2-(4-fluorophenyl)-2-(4-isopropylpiperazino)ethyl]-4-(3-biphenyl-2-ylpropionyl)piperazine

Base Information

Chemical Name:1-[2-(4-fluorophenyl)-2-(4-isopropylpiperazino)ethyl]-4-(3-biphenyl-2-ylpropionyl)piperazine
CAS No.:552885-53-7
Molecular Formula:C₃₄H₄₃FN₄O
Molecular Weight:542.74
Hs Code.:

Synonyms:1-[2-(4-fluorophenyl)-2-(4-isopropylpiperazino)ethyl]-4-(3-biphenyl-2-ylpropionyl)piperazine

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Chemical Property of 1-[2-(4-fluorophenyl)-2-(4-isopropylpiperazino)ethyl]-4-(3-biphenyl-2-ylpropionyl)piperazine

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Technology Process of 1-[2-(4-fluorophenyl)-2-(4-isopropylpiperazino)ethyl]-4-(3-biphenyl-2-ylpropionyl)piperazine

There total 4 articles about 1-[2-(4-fluorophenyl)-2-(4-isopropylpiperazino)ethyl]-4-(3-biphenyl-2-ylpropionyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 686710-22-5
(+/-)-1-[1-(4-fluorophenyl)-2-piperazin-1-ylethyl]-4-isopropylpiperazine

: 19853-17-9
3-(biphenyl-2-yl)propanoic acid

: 552885-53-7
1-[2-(4-fluorophenyl)-2-(4-isopropylpiperazino)ethyl]-4-(3-biphenyl-2-ylpropionyl)piperazine

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/j.bmc.2006.12.039

Reference yield:

: 552885-52-6
ethyl 4-[2-(4-fluorophenyl)-2-(4-isopropylpiperazin-1-yl)ethyl]piperazine-1-carboxylate

: 552885-53-7
1-[2-(4-fluorophenyl)-2-(4-isopropylpiperazino)ethyl]-4-(3-biphenyl-2-ylpropionyl)piperazine

Guidance literature:: Multi-step reaction with 2 steps

1: KOH / ethanol / 1 h / Heating

2: HOBt*H₂O; EDC*HCl / dimethylformamide / 20 °C

With potassium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.12.039

Reference yield:

: 89011-47-2
ethyl 4-[2-(4-fluorophenyl)-2-hydroxyethyl]piperazine-1-carboxylate hydrochloride

: 552885-53-7
1-[2-(4-fluorophenyl)-2-(4-isopropylpiperazino)ethyl]-4-(3-biphenyl-2-ylpropionyl)piperazine

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride / benzene / 0.17 h / 50 °C

2: 9.60 g / ethyldiisopropylamine / benzene / 6 h / 60 °C

3: KOH / ethanol / 1 h / Heating

4: HOBt*H₂O; EDC*HCl / dimethylformamide / 20 °C

With potassium hydroxide; thionyl chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In ethanol; N,N-dimethyl-formamide; benzene;
DOI:10.1016/j.bmc.2006.12.039