6-fluoro-1-isopropyl-2-({1-[2-(3-methoxyphenyl)ethyl]piperidin-4-yl}carbonyl)-1,2,3,4-tetrahydroisoquinoline oxalate

Base Information

Chemical Name:6-fluoro-1-isopropyl-2-({1-[2-(3-methoxyphenyl)ethyl]piperidin-4-yl}carbonyl)-1,2,3,4-tetrahydroisoquinoline oxalate
CAS No.:1344029-77-1
Molecular Formula:C₂H₂O₄*C₂₇H₃₅FN₂O₂
Molecular Weight:528.621
Hs Code.:

Synonyms:6-fluoro-1-isopropyl-2-({1-[2-(3-methoxyphenyl)ethyl]piperidin-4-yl}carbonyl)-1,2,3,4-tetrahydroisoquinoline oxalate

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Chemical Property of 6-fluoro-1-isopropyl-2-({1-[2-(3-methoxyphenyl)ethyl]piperidin-4-yl}carbonyl)-1,2,3,4-tetrahydroisoquinoline oxalate

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Technology Process of 6-fluoro-1-isopropyl-2-({1-[2-(3-methoxyphenyl)ethyl]piperidin-4-yl}carbonyl)-1,2,3,4-tetrahydroisoquinoline oxalate

There total 5 articles about 6-fluoro-1-isopropyl-2-({1-[2-(3-methoxyphenyl)ethyl]piperidin-4-yl}carbonyl)-1,2,3,4-tetrahydroisoquinoline oxalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 25112-95-2
toluene-4-sulfonic acid 2-(3-methoxyphenyl)-ethyl ester

: 1344029-15-7
4-[(6-fluoro-1-isopropyl-1,2,3,4-tetrahydroisoquinolin-2-yl)carbonyl]piperidine

: 144-62-7,97993-78-7
oxalic acid

: 1344029-77-1
6-fluoro-1-isopropyl-2-({1-[2-(3-methoxyphenyl)ethyl]piperidin-4-yl}carbonyl)-1,2,3,4-tetrahydroisoquinoline oxalate

Guidance literature:: toluene-4-sulfonic acid 2-(3-methoxyphenyl)-ethyl ester; 4-[(6-fluoro-1-isopropyl-1,2,3,4-tetrahydroisoquinolin-2-yl)carbonyl]piperidine; With potassium carbonate; In acetonitrile; at 70 ℃; for 15h;

oxalic acid;
DOI:10.1248/cpb.59.1029

Reference yield:

: 1085543-18-5
6-fluoro-1-isopropyl-1,2,3,4-tetrahydroisoquinoline hydrochloride

: 1344029-77-1
6-fluoro-1-isopropyl-2-({1-[2-(3-methoxyphenyl)ethyl]piperidin-4-yl}carbonyl)-1,2,3,4-tetrahydroisoquinoline oxalate

Guidance literature:: Multi-step reaction with 3 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 120 h / 20 °C / Cooling with ice

2: hydrogenchloride / ethyl acetate / 24 h / 20 °C / Cooling with ice

3: potassium carbonate / acetonitrile / 15 h / 70 °C

With hydrogenchloride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1248/cpb.59.1029

Reference yield:

: 1085542-44-4
6-fluoro-1-isopropyl-3,4-dihydroisoquinoline

: 1344029-77-1
6-fluoro-1-isopropyl-2-({1-[2-(3-methoxyphenyl)ethyl]piperidin-4-yl}carbonyl)-1,2,3,4-tetrahydroisoquinoline oxalate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium tetrahydroborate / ethanol / 2 h / 20 °C / Cooling with ice

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 120 h / 20 °C / Cooling with ice

3: hydrogenchloride / ethyl acetate / 24 h / 20 °C / Cooling with ice

4: potassium carbonate / acetonitrile / 15 h / 70 °C

With hydrogenchloride; sodium tetrahydroborate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In ethanol; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1248/cpb.59.1029