3-[(2'Z)-3'-amino-1'-oxo-2'-buten-1'-yl]-6-fluoro-2-(4-methylphenyl)-4-pentafluoroethyl-5-trifluoromethylpyridine

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Chemical Name:3-[(2'Z)-3'-amino-1'-oxo-2'-buten-1'-yl]-6-fluoro-2-(4-methylphenyl)-4-pentafluoroethyl-5-trifluoromethylpyridine
CAS No.:947328-22-5
Molecular Formula:C₁₉H₁₃F₉N₂O
Molecular Weight:456.311
Hs Code.:

Synonyms:3-[(2'Z)-3'-amino-1'-oxo-2'-buten-1'-yl]-6-fluoro-2-(4-methylphenyl)-4-pentafluoroethyl-5-trifluoromethylpyridine

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Chemical Property of 3-[(2'Z)-3'-amino-1'-oxo-2'-buten-1'-yl]-6-fluoro-2-(4-methylphenyl)-4-pentafluoroethyl-5-trifluoromethylpyridine

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Technology Process of 3-[(2'Z)-3'-amino-1'-oxo-2'-buten-1'-yl]-6-fluoro-2-(4-methylphenyl)-4-pentafluoroethyl-5-trifluoromethylpyridine

There total 4 articles about 3-[(2'Z)-3'-amino-1'-oxo-2'-buten-1'-yl]-6-fluoro-2-(4-methylphenyl)-4-pentafluoroethyl-5-trifluoromethylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 947328-04-3
2-fluoro-5-(3'-methylisoxazol-5'-yl)-6-(4-methylphenyl)-4-pentafluoroethyl-3-trifluoromethylpyridine

: 947328-22-5
3-[(2'Z)-3'-amino-1'-oxo-2'-buten-1'-yl]-6-fluoro-2-(4-methylphenyl)-4-pentafluoroethyl-5-trifluoromethylpyridine

Guidance literature:: With hydrogen; platinum(IV) oxide; In ethanol; at 20 ℃; for 12h; under 760.051 Torr;
DOI:10.1021/jo070564m

Reference yield:

: 1584-03-8
perfluoro-2-methylpent-2-ene

: 947328-22-5
3-[(2'Z)-3'-amino-1'-oxo-2'-buten-1'-yl]-6-fluoro-2-(4-methylphenyl)-4-pentafluoroethyl-5-trifluoromethylpyridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: nBuLi / hexane; tetrahydrofuran / 1 h / -70 °C

1.2: hexane; tetrahydrofuran / 3 h / -70 - 20 °C

1.3: 55 percent / tetrahydrofuran; hexane / 24 h / -70 - 20 °C

2.1: 91 percent / H₂ / PtO₂ / ethanol / 12 h / 20 °C / 760.05 Torr

With n-butyllithium; hydrogen; platinum(IV) oxide; In tetrahydrofuran; ethanol; hexane;
DOI:10.1021/jo070564m

Reference yield:

: 75632-83-6
3-methyl-5-[(trimethylsilyl)methyl]isoxazole

: 947328-22-5
3-[(2'Z)-3'-amino-1'-oxo-2'-buten-1'-yl]-6-fluoro-2-(4-methylphenyl)-4-pentafluoroethyl-5-trifluoromethylpyridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: nBuLi / hexane; tetrahydrofuran / 1 h / -70 °C

1.2: hexane; tetrahydrofuran / 3 h / -70 - 20 °C

1.3: 55 percent / tetrahydrofuran; hexane / 24 h / -70 - 20 °C

2.1: 91 percent / H₂ / PtO₂ / ethanol / 12 h / 20 °C / 760.05 Torr

With n-butyllithium; hydrogen; platinum(IV) oxide; In tetrahydrofuran; ethanol; hexane;
DOI:10.1021/jo070564m