5-(3-(3-(4-fluorophenyl)-2-oxoimidazolidin-1-yl)-2-methylphenyl)-1-methyl-3-((4-(morpholine-4-carbonyl)phenyl)amino)pyrazin-2(1H)-one

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Chemical Name:5-(3-(3-(4-fluorophenyl)-2-oxoimidazolidin-1-yl)-2-methylphenyl)-1-methyl-3-((4-(morpholine-4-carbonyl)phenyl)amino)pyrazin-2(1H)-one
CAS No.:1620088-93-8
Molecular Formula:C₃₂H₃₁FN₆O₄
Molecular Weight:582.634
Hs Code.:

Synonyms:5-(3-(3-(4-fluorophenyl)-2-oxoimidazolidin-1-yl)-2-methylphenyl)-1-methyl-3-((4-(morpholine-4-carbonyl)phenyl)amino)pyrazin-2(1H)-one

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Chemical Property of 5-(3-(3-(4-fluorophenyl)-2-oxoimidazolidin-1-yl)-2-methylphenyl)-1-methyl-3-((4-(morpholine-4-carbonyl)phenyl)amino)pyrazin-2(1H)-one

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Technology Process of 5-(3-(3-(4-fluorophenyl)-2-oxoimidazolidin-1-yl)-2-methylphenyl)-1-methyl-3-((4-(morpholine-4-carbonyl)phenyl)amino)pyrazin-2(1H)-one

There total 8 articles about 5-(3-(3-(4-fluorophenyl)-2-oxoimidazolidin-1-yl)-2-methylphenyl)-1-methyl-3-((4-(morpholine-4-carbonyl)phenyl)amino)pyrazin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.08%

: 352-34-1
4-fluoro-1-iodobenzene

: 1620090-01-8
1-methyl-5-(2-methyl-3-(2-oxoimidazolidin-1-yl)phenyl)-3-((4-(morpholine-4-carbonyl)phenyl)amino)pyrazin-2(1H)-one

: 1620088-93-8
5-(3-(3-(4-fluorophenyl)-2-oxoimidazolidin-1-yl)-2-methylphenyl)-1-methyl-3-((4-(morpholine-4-carbonyl)phenyl)amino)pyrazin-2(1H)-one

Guidance literature:: With copper(l) iodide; caesium carbonate; N,N-dimethylethylenediamine; In 1,4-dioxane; at 120 ℃; for 16h; Inert atmosphere; Sealed tube;

Reference yield:

: 1620089-71-5
1-(2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)imidazolidin-2-one

: 1620088-93-8
5-(3-(3-(4-fluorophenyl)-2-oxoimidazolidin-1-yl)-2-methylphenyl)-1-methyl-3-((4-(morpholine-4-carbonyl)phenyl)amino)pyrazin-2(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / water / 0.08 h / Inert atmosphere; Sealed tube

1.2: 16 h / 120 °C / Inert atmosphere; Sealed tube

2.1: N,N-dimethylethylenediamine; caesium carbonate; copper(l) iodide / 1,4-dioxane / 16 h / 120 °C / Inert atmosphere; Sealed tube

With copper(l) iodide; potassium carbonate; caesium carbonate; N,N-dimethylethylenediamine; In 1,4-dioxane; water;

Reference yield:

: 1620089-70-4
1-(3-bromo-2-methylphenyl)imidazolidin-2-one

: 1620088-93-8
5-(3-(3-(4-fluorophenyl)-2-oxoimidazolidin-1-yl)-2-methylphenyl)-1-methyl-3-((4-(morpholine-4-carbonyl)phenyl)amino)pyrazin-2(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium acetate / 1,4-dioxane / 0.17 h / Sealed tube; Inert atmosphere

1.2: 16 h / 110 °C / Sealed tube; Inert atmosphere

2.1: potassium carbonate / water / 0.08 h / Inert atmosphere; Sealed tube

2.2: 16 h / 120 °C / Inert atmosphere; Sealed tube

3.1: N,N-dimethylethylenediamine; caesium carbonate; copper(l) iodide / 1,4-dioxane / 16 h / 120 °C / Inert atmosphere; Sealed tube

With copper(l) iodide; potassium acetate; potassium carbonate; caesium carbonate; N,N-dimethylethylenediamine; In 1,4-dioxane; water;