(5-Amino-2-methyl-phenyl)-[2-chloro-4-(2,4-difluoro-phenylamino)-phenyl]-methanone

Base Information

• Chemical Name: (5-Amino-2-methyl-phenyl)-[2-chloro-4-(2,4-difluoro-phenylamino)-phenyl]-methanone
• CAS No.: 1026274-28-1
• Molecular Formula: C₂₀H₁₅ClF₂N₂O
• Molecular Weight: 372.802

Synonyms:(5-Amino-2-methyl-phenyl)-[2-chloro-4-(2,4-difluoro-phenylamino)-phenyl]-methanone

Chemical Property of (5-Amino-2-methyl-phenyl)-[2-chloro-4-(2,4-difluoro-phenylamino)-phenyl]-methanone

Chemical Property:

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Technology Process of (5-Amino-2-methyl-phenyl)-[2-chloro-4-(2,4-difluoro-phenylamino)-phenyl]-methanone

There total 1 articles about (5-Amino-2-methyl-phenyl)-[2-chloro-4-(2,4-difluoro-phenylamino)-phenyl]-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[2-Chloro-4-(2,4-difluoro-phenylamino)-phenyl]-(2-methyl-5-nitro-phenyl)-methanone → (5-Amino-2-methyl-phenyl)-[2-chloro-4-(2,4-difluoro-phenylamino)-phenyl]-methanone (1026274-28-1)

Guidance literature:

With ammonium chloride; zinc; In methanol; for 1h; Heating / reflux;

Reference yield:

(5-Amino-2-methyl-phenyl)-[2-chloro-4-(2,4-difluoro-phenylamino)-phenyl]-methanone (1026274-28-1) → [2-chloro-4-(2,4-difluorophenylamino)phenyl]-(5-iodo-2-methylphenyl)methanone (1056188-11-4)

Guidance literature:

(5-Amino-2-methyl-phenyl)-[2-chloro-4-(2,4-difluoro-phenylamino)-phenyl]-methanone; With hydrogenchloride; sodium nitrite; In water; acetone; at -2 - 0 ℃; for 0.5h;

With iodine; potassium iodide; In water; acetone; at 0 ℃; for 2.08333h;

Reference yield:

(5-Amino-2-methyl-phenyl)-[2-chloro-4-(2,4-difluoro-phenylamino)-phenyl]-methanone (1026274-28-1) → 3-[2-chloro-4-(2,4-difluoro-phenylamino)-benzoyl]-4-methyl-benzenesulfonyl chloride

Guidance literature:

(5-Amino-2-methyl-phenyl)-[2-chloro-4-(2,4-difluoro-phenylamino)-phenyl]-methanone; With hydrogenchloride; acetic acid; In water; acetonitrile; at 20 ℃;

With sodium nitrite; In water; acetonitrile; at 0 - 2 ℃; for 0.583333h;

With sulfur dioxide; copper(l) chloride; copper dichloride; more than 3 stages;

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