(3R,4S)-3-benzyloxymethyl-4-trifluoromethyl-2,2-dioxo-1,3,2-dioxathiolane

Base Information

Chemical Name:(3R,4S)-3-benzyloxymethyl-4-trifluoromethyl-2,2-dioxo-1,3,2-dioxathiolane
CAS No.:610272-59-8
Molecular Formula:C₁₁H₁₁F₃O₅S
Molecular Weight:312.267
Hs Code.:

Synonyms:(3R,4S)-3-benzyloxymethyl-4-trifluoromethyl-2,2-dioxo-1,3,2-dioxathiolane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R,4S)-3-benzyloxymethyl-4-trifluoromethyl-2,2-dioxo-1,3,2-dioxathiolane

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Technology Process of (3R,4S)-3-benzyloxymethyl-4-trifluoromethyl-2,2-dioxo-1,3,2-dioxathiolane

There total 4 articles about (3R,4S)-3-benzyloxymethyl-4-trifluoromethyl-2,2-dioxo-1,3,2-dioxathiolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 610272-47-4
(E)-(((4,4,4-trifluorobut-2-en-1-yl)oxy)methyl)benzene

: 610272-59-8
(3R,4S)-3-benzyloxymethyl-4-trifluoromethyl-2,2-dioxo-1,3,2-dioxathiolane

Guidance literature:: Multi-step reaction with 2 steps

1.1: 93 percent / (DHQ)PHAL; OsO₄; K₂CO₃ / K₃Fe(CN)6; MeSO₂NH₄ / 2-methyl-propan-2-ol; H₂O / 48 h / 20 °C

2.1: SOCl₂; Et₃N

2.2: NaIO₄; RuCl₃

With osmium(VIII) oxide; thionyl chloride; potassium carbonate; 4-[(R)-[(2R,4R,5S)-5-ethyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxy-4-quinolinyl)methoxy]-1-[(R)-[(2R,4S,5R)-5-ethyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxy-4-quinolinyl)methoxy]phthalazine; triethylamine; MeSO₂NH₄; potassium hexacyanoferrate(III); In water; tert-butyl alcohol; 1.1: Sharpless asymmetric epoxidation;
DOI:10.1021/jo0497611

Reference yield:

: (4R,5S)-4-Benzyloxymethyl-5-trifluoromethyl-[1,3,2]dioxathiolane 2-oxide

: 610272-59-8
(3R,4S)-3-benzyloxymethyl-4-trifluoromethyl-2,2-dioxo-1,3,2-dioxathiolane

Guidance literature:: With ruthenium trichloride; sodium periodate; In tetrachloromethane; water; acetonitrile; at 20 ℃; for 1h;
DOI:10.1021/jo0344384

Reference yield:

: 610272-58-7
(2R,3S)-1-benzyloxy-4,4,4-trifluoro-2,3-butanediol

: 610272-59-8
(3R,4S)-3-benzyloxymethyl-4-trifluoromethyl-2,2-dioxo-1,3,2-dioxathiolane

Guidance literature:: (2R,3S)-1-benzyloxy-4,4,4-trifluoro-2,3-butanediol; With thionyl chloride; triethylamine;

With ruthenium trichloride; sodium periodate;
DOI:10.1021/jo0497611