ethyl 2-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-(2-((tert-butyldimethylsilyl)oxy)ethyl)thiazole-4-carboxylate

Base Information

Chemical Name:ethyl 2-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-(2-((tert-butyldimethylsilyl)oxy)ethyl)thiazole-4-carboxylate
CAS No.:1235035-46-7
Molecular Formula:C₃₁H₃₈N₄O₄S₂Si
Molecular Weight:622.885
Hs Code.:

Synonyms:ethyl 2-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-(2-((tert-butyldimethylsilyl)oxy)ethyl)thiazole-4-carboxylate

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Chemical Property of ethyl 2-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-(2-((tert-butyldimethylsilyl)oxy)ethyl)thiazole-4-carboxylate

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Technology Process of ethyl 2-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-(2-((tert-butyldimethylsilyl)oxy)ethyl)thiazole-4-carboxylate

There total 1 articles about ethyl 2-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-(2-((tert-butyldimethylsilyl)oxy)ethyl)thiazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 878798-87-9
2-(tert-butoxycarbonyl)-1,2,3 ,4-tetrahydroisoquinoline-8-carboxylic acid

: 1235035-46-7
ethyl 2-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-(2-((tert-butyldimethylsilyl)oxy)ethyl)thiazole-4-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 20 °C

2.1: hydrogenchloride / water; dichloromethane; diethyl ether / 20 °C

3.1: triethylamine / N,N-dimethyl-formamide / 0.17 h

3.2: 0.5 h / 20 °C

4.1: ammonia / methanol

5.1: N,N-dimethyl-formamide / 8 h / 50 °C

With hydrogenchloride; dmap; ammonia; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/ml500030p

Reference yield:

: 1235035-46-7
ethyl 2-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-(2-((tert-butyldimethylsilyl)oxy)ethyl)thiazole-4-carboxylate

: 108-95-2,27073-41-2
phenol

: 1235033-79-0
2-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-(2-phenoxyethyl)thiazole-4-carboxylic acid

Guidance literature:: ethyl 2-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-(2-((tert-butyldimethylsilyl)oxy)ethyl)thiazole-4-carboxylate; With (2-trimethylethylsilylethoxy)methyl chloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

With hydrogenchloride; In methanol; dichloromethane; at 20 ℃; for 5h;

phenol;

Reference yield:

: 1235035-46-7
ethyl 2-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-(2-((tert-butyldimethylsilyl)oxy)ethyl)thiazole-4-carboxylate

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 108-95-2,27073-41-2
phenol

: C₃₅H₃₈N₄O₅S₂Si

Guidance literature:: ethyl 2-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-(2-((tert-butyldimethylsilyl)oxy)ethyl)thiazole-4-carboxylate; (2-trimethylethylsilylethoxy)methyl chloride; With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

With hydrogenchloride; In methanol; dichloromethane; at 20 ℃; for 5h;

phenol; Further stages;
DOI:10.1021/ml500030p