Technology Process of p-<(4'-Nitrophenyl)-azo>-(N-ethyl-N-β-bromethyl)-anilin
There total 1 articles about p-<(4'-Nitrophenyl)-azo>-(N-ethyl-N-β-bromethyl)-anilin which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
carbon tetrabromide; triphenylphosphine;
In
dichloromethane;
at 0 - 20 ℃;
for 4h;
Inert atmosphere;
DOI:10.1021/ja408104w
- Guidance literature:
-
Multi-step reaction with 7 steps
1: N,N-dimethyl-formamide / 12 h / 90 °C / Inert atmosphere
2: hydrazine hydrate / ethanol / 4 h / 60 °C / Inert atmosphere
3: sodium sulfide / water; 1,4-dioxane / 6 h / 90 °C
4: N-ethyl-N,N-diisopropylamine / dichloromethane / 24 h / 20 °C / Inert atmosphere
5: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 48 h / 20 °C / Inert atmosphere
6: piperidine / tetrahydrofuran / 1.5 h / Inert atmosphere
7: lithium hydroxide / water; tetrahydrofuran / 2 h / 0 - 20 °C
With
piperidine; sodium sulfide; benzotriazol-1-ol; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
2: |Gabriel Amine Synthesis;
DOI:10.1021/ja408104w
- Guidance literature:
-
Multi-step reaction with 8 steps
1: N,N-dimethyl-formamide / 12 h / 90 °C / Inert atmosphere
2: hydrazine hydrate / ethanol / 4 h / 60 °C / Inert atmosphere
3: sodium sulfide / water; 1,4-dioxane / 6 h / 90 °C
4: N-ethyl-N,N-diisopropylamine / dichloromethane / 24 h / 20 °C / Inert atmosphere
5: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 48 h / 20 °C / Inert atmosphere
6: piperidine / tetrahydrofuran / 1.5 h / Inert atmosphere
7: lithium hydroxide / water; tetrahydrofuran / 2 h / 0 - 20 °C
8: sodium hydrogencarbonate / water; tetrahydrofuran / 0.25 h / 0 °C
With
piperidine; sodium sulfide; sodium hydrogencarbonate; benzotriazol-1-ol; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
2: |Gabriel Amine Synthesis;
DOI:10.1021/ja408104w
