Dihydrexidine

Base Information

Chemical Name:Dihydrexidine
CAS No.:123039-93-0
Deprecated CAS:126295-91-8
Molecular Formula:C₁₇H₁₇NO₂
Molecular Weight:267.327
Hs Code.:
UNII:32D64VH037,U4MPC92UC2
DSSTox Substance ID:DTXSID00894188
Nikkaji Number:J605.727F
Wikipedia:Dihydrexidine
Wikidata:Q5276413
Pharos Ligand ID:PU4W7W3CP9BX
Metabolomics Workbench ID:153788
ChEMBL ID:CHEMBL4280145
Mol file:123039-93-0.mol

Synonyms:10,11-dihydroxyhexahydrobenzo(a)phenanthridine;DAR 0100A;DAR-0100A;DAR0100A;dihydrexidine

Suppliers and Price of Dihydrexidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Dihydrexidine
10mg
$ 1320.00

Tocris
Dihydrexidinehydrochloride ≥98%(HPLC)
5
$ 171.00

Tocris
Dihydrexidinehydrochloride ≥98%(HPLC)
25
$ 675.00

American Custom Chemicals Corporation
DIHYDREXIDINE HYDROCHLORIDE 95.00%
5MG
$ 496.02

Total 9 raw suppliers

Chemical Property of Dihydrexidine

Chemical Property:

Vapor Pressure:3.7E-10mmHg at 25°C
Boiling Point:488.3°Cat760mmHg
Flash Point:190.5°C
PSA：52.49000
Density:1.267g/cm³
LogP:3.77850
Storage Temp.:2-8°C
XLogP3:2.5
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:0
Exact Mass:267.125928785
Heavy Atom Count:20
Complexity:361

Purity/Quality:

≥95% ^*data from raw suppliers

Dihydrexidine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CC2=CC(=C(C=C2C3C1NCC4=CC=CC=C34)O)O
Isomeric SMILES:C1CC2=CC(=C(C=C2[C@H]3[C@H]1NCC4=CC=CC=C34)O)O
Recent ClinicalTrials:Infusion Laboratory: Protocol 4 (Dihydrexidine) - 13
Uses Dihydrexidine is a moderately selective full agonist at the dopamine D1 and D5 receptors (1,2). It has been shown to have antiparkinson effects. It also has the ability to improving the cognitive and working memory deficits in schizophrenia and schizotypal disorder.

Technology Process of Dihydrexidine

There total 26 articles about Dihydrexidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: trans-10,11-dimethoxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine hydrochloride

: 123039-93-0
(6a,12b)-trans-10,11-dihydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine

Guidance literature:: trans-10,11-dimethoxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine hydrochloride; With hydrogen bromide; In water; for 3h; Heating / reflux;

With sodium hydrogencarbonate; In water;

Reference yield:

: 406499-03-4
(6aR,12bS)-(+)-10,11-dimethoxy-5,6,6a,7,8,12b-hexahydrobenzo phenanthridine

: 174691-84-0,123039-93-0
dihydrexidine

Guidance literature:: With boron tribromide; In dichloromethane; Ambient temperature;
DOI:10.1021/jm00041a025

Reference yield:

: 126296-09-1
trans-6-benzyl-10,11-dimethoxy-5,6,6a,7,8,12b-hexahydrobenzo phenanthridine hydrochloride

: 126295-91-8,123039-93-0
dihydrexidine

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / H₂ / 10percent Pd/C / aq. ethanol / 8 h / 2585.7 Torr / Ambient temperature

2: aq. 48percent HBr / 3 h / Heating

With hydrogen bromide; hydrogen; palladium on activated charcoal; In ethanol;
DOI:10.1021/jm00168a034