methyl (S)-4-methyl-2-[2-[(S)-4-methyl-2-(2-nitrobenzamido)pentanamido]benzamido]pentanoate

Base Information

Chemical Name:methyl (S)-4-methyl-2-[2-[(S)-4-methyl-2-(2-nitrobenzamido)pentanamido]benzamido]pentanoate
CAS No.:1297471-95-4
Molecular Formula:C₂₇H₃₄N₄O₇
Molecular Weight:526.59
Hs Code.:

Synonyms:methyl (S)-4-methyl-2-[2-[(S)-4-methyl-2-(2-nitrobenzamido)pentanamido]benzamido]pentanoate

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Chemical Property of methyl (S)-4-methyl-2-[2-[(S)-4-methyl-2-(2-nitrobenzamido)pentanamido]benzamido]pentanoate

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Technology Process of methyl (S)-4-methyl-2-[2-[(S)-4-methyl-2-(2-nitrobenzamido)pentanamido]benzamido]pentanoate

There total 4 articles about methyl (S)-4-methyl-2-[2-[(S)-4-methyl-2-(2-nitrobenzamido)pentanamido]benzamido]pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: (S)-N-(2-nitrobenzoyl)leucine

: N-(2-aminobenzoyl)-S-leucine methyl ester

: 1297471-95-4
methyl (S)-4-methyl-2-[2-[(S)-4-methyl-2-(2-nitrobenzamido)pentanamido]benzamido]pentanoate

Guidance literature:: With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; In chloroform; at 0 - 20 ℃; for 17h;
DOI:10.1002/chir.20972

Reference yield:

: 474089-60-6
methyl (S)-N-(2-nitrobenzoyl)leucinate

: 1297471-95-4
methyl (S)-4-methyl-2-[2-[(S)-4-methyl-2-(2-nitrobenzamido)pentanamido]benzamido]pentanoate

Guidance literature:: Multi-step reaction with 2 steps

1: water; lithium hydroxide / tetrahydrofuran / 1 h / 20 °C

2: N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline / chloroform / 17 h / 0 - 20 °C

With water; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; lithium hydroxide; In tetrahydrofuran; chloroform;
DOI:10.3987/COM-10-S(E)58

Reference yield:

: 552-16-9,104810-18-6
ortho-nitrobenzoic acid

: 1297471-95-4
methyl (S)-4-methyl-2-[2-[(S)-4-methyl-2-(2-nitrobenzamido)pentanamido]benzamido]pentanoate

Guidance literature:: Multi-step reaction with 3 steps

1: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide / tetrahydrofuran / 26 h / 0 - 20 °C

2: water; lithium hydroxide / tetrahydrofuran / 1 h / 20 °C

3: N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline / chloroform / 17 h / 0 - 20 °C

With water; benzotriazol-1-ol; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; lithium hydroxide; In tetrahydrofuran; chloroform;
DOI:10.3987/COM-10-S(E)58