methyl 2-(3-(4-chlorophenyl)-5-oxo-2-thioxo-8-(trifluoromethyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)-2-(4-fluorophenyl)acetate

Base Information

Chemical Name:methyl 2-(3-(4-chlorophenyl)-5-oxo-2-thioxo-8-(trifluoromethyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)-2-(4-fluorophenyl)acetate
CAS No.:1413931-29-9
Molecular Formula:C₂₅H₁₇ClF₄N₂O₃S
Molecular Weight:536.934
Hs Code.:

Synonyms:methyl 2-(3-(4-chlorophenyl)-5-oxo-2-thioxo-8-(trifluoromethyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)-2-(4-fluorophenyl)acetate

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Chemical Property of methyl 2-(3-(4-chlorophenyl)-5-oxo-2-thioxo-8-(trifluoromethyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)-2-(4-fluorophenyl)acetate

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Technology Process of methyl 2-(3-(4-chlorophenyl)-5-oxo-2-thioxo-8-(trifluoromethyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)-2-(4-fluorophenyl)acetate

There total 4 articles about methyl 2-(3-(4-chlorophenyl)-5-oxo-2-thioxo-8-(trifluoromethyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)-2-(4-fluorophenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1413931-11-9
C₂₅H₁₇ClF₄N₂O₄

: 1413931-29-9
methyl 2-(3-(4-chlorophenyl)-5-oxo-2-thioxo-8-(trifluoromethyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)-2-(4-fluorophenyl)acetate

Guidance literature:: With Lawessons reagent; In toluene; at 70 ℃; for 4h; Inert atmosphere;
DOI:10.1016/j.ejmech.2012.08.003

Reference yield:

: C₃₁H₂₂ClF₄N₃O₆

: 1413931-29-9
methyl 2-(3-(4-chlorophenyl)-5-oxo-2-thioxo-8-(trifluoromethyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)-2-(4-fluorophenyl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: iron / acetic acid / 1 h / 50 - 70 °C

2: Lawessons reagent / toluene / 4 h / 70 °C / Inert atmosphere

With Lawessons reagent; iron; In acetic acid; toluene;
DOI:10.1016/j.ejmech.2012.08.003

Reference yield:

: 320-94-5
2-nitro-4-trifluoromethylbenzoic acid

: 1413931-29-9
methyl 2-(3-(4-chlorophenyl)-5-oxo-2-thioxo-8-(trifluoromethyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)-2-(4-fluorophenyl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide / methanol / 0.17 h / 20 °C

1.2: 24 h / 0 - 20 °C

2.1: iron / acetic acid / 1 h / 50 - 70 °C

3.1: Lawessons reagent / toluene / 4 h / 70 °C / Inert atmosphere

With Lawessons reagent; iron; potassium hydroxide; In methanol; acetic acid; toluene; 1.1: |Ugi Condensation;
DOI:10.1016/j.ejmech.2012.08.003