(2S)-1-((2S,4R)-4-benzyl-5-{[(3S,4S)-3-hydroxy-3,4-dihydro-2H-chromen-4-yl]amino}-2-hydroxy-5-oxopentyl)-N-(2,2,2-trifluoroethyl)piperazine-2-carboxamide

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Chemical Name:(2S)-1-((2S,4R)-4-benzyl-5-{[(3S,4S)-3-hydroxy-3,4-dihydro-2H-chromen-4-yl]amino}-2-hydroxy-5-oxopentyl)-N-(2,2,2-trifluoroethyl)piperazine-2-carboxamide
CAS No.:342600-53-7
Molecular Formula:C₂₈H₃₅F₃N₄O₅
Molecular Weight:564.605
Hs Code.:

Synonyms:(2S)-1-((2S,4R)-4-benzyl-5-{[(3S,4S)-3-hydroxy-3,4-dihydro-2H-chromen-4-yl]amino}-2-hydroxy-5-oxopentyl)-N-(2,2,2-trifluoroethyl)piperazine-2-carboxamide

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Chemical Property of (2S)-1-((2S,4R)-4-benzyl-5-{[(3S,4S)-3-hydroxy-3,4-dihydro-2H-chromen-4-yl]amino}-2-hydroxy-5-oxopentyl)-N-(2,2,2-trifluoroethyl)piperazine-2-carboxamide

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Technology Process of (2S)-1-((2S,4R)-4-benzyl-5-{[(3S,4S)-3-hydroxy-3,4-dihydro-2H-chromen-4-yl]amino}-2-hydroxy-5-oxopentyl)-N-(2,2,2-trifluoroethyl)piperazine-2-carboxamide

There total 12 articles about (2S)-1-((2S,4R)-4-benzyl-5-{[(3S,4S)-3-hydroxy-3,4-dihydro-2H-chromen-4-yl]amino}-2-hydroxy-5-oxopentyl)-N-(2,2,2-trifluoroethyl)piperazine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 342600-52-6
tert-butyl (3S)-4-{(2S,4R)-4-benzyl-5-[(3aS,9bS)-2,2-dimethyl-3a,9b-dihydro-2H-chromeno[4,3-d][1,3]oxazol-1(4H)-yl]-2-hydroxy-5-oxopentyl}-3-{[(2,2,2-trifluoroethyl)amino]carbonyl}piperazine-1-carboxylate

: 342600-53-7
(2S)-1-((2S,4R)-4-benzyl-5-{[(3S,4S)-3-hydroxy-3,4-dihydro-2H-chromen-4-yl]amino}-2-hydroxy-5-oxopentyl)-N-(2,2,2-trifluoroethyl)piperazine-2-carboxamide

Guidance literature:: With hydrogenchloride; In Isopropyl acetate; at 6 ℃; for 4h;
DOI:10.1016/j.tetasy.2003.09.023

Reference yield:

: 98-97-5
2-pyrazylcarboxylic acid

: 342600-53-7
(2S)-1-((2S,4R)-4-benzyl-5-{[(3S,4S)-3-hydroxy-3,4-dihydro-2H-chromen-4-yl]amino}-2-hydroxy-5-oxopentyl)-N-(2,2,2-trifluoroethyl)piperazine-2-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: 1-hydroxybenzotriazole; triethylamine; EDC*HCl / dimethylformamide / 25 - 35 °C

2: H₂ / Pd(OH)2/C / ethanol / 10 h / 10 - 62 °C / 258.57 - 2068.59 Torr

3: (1S)-(+)-10-camphorsulfonic acid / ethanol; acetonitrile; H₂O / 20 - 73 °C

4: 88 percent Chromat_. / triethylamine / isopropyl acetate; acetonitrile; H₂O / 2.5 h

5: isopropyl acetate / 64 h / 90 °C

6: 99.1 g / HCl / isopropyl acetate / 4 h / 6 °C

With hydrogenchloride; hydrogen; benzotriazol-1-ol; (+)-10-camphorsulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium dihydroxide; In ethanol; Isopropyl acetate; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.tetasy.2003.09.023

Reference yield:

: 342603-60-5
N-(2,2,2-trifluoroethyl)pyrazine-2-carboxamide

: 342600-53-7
(2S)-1-((2S,4R)-4-benzyl-5-{[(3S,4S)-3-hydroxy-3,4-dihydro-2H-chromen-4-yl]amino}-2-hydroxy-5-oxopentyl)-N-(2,2,2-trifluoroethyl)piperazine-2-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: H₂ / Pd(OH)2/C / ethanol / 10 h / 10 - 62 °C / 258.57 - 2068.59 Torr

2: (1S)-(+)-10-camphorsulfonic acid / ethanol; acetonitrile; H₂O / 20 - 73 °C

3: 88 percent Chromat_. / triethylamine / isopropyl acetate; acetonitrile; H₂O / 2.5 h

4: isopropyl acetate / 64 h / 90 °C

5: 99.1 g / HCl / isopropyl acetate / 4 h / 6 °C

With hydrogenchloride; hydrogen; (+)-10-camphorsulfonic acid; triethylamine; palladium dihydroxide; In ethanol; Isopropyl acetate; water; acetonitrile;
DOI:10.1016/j.tetasy.2003.09.023