Technology Process of (R)-5-(3-bromo-phenyl)-2,2,5-trimethyl-morpholin-3-one
There total 4 articles about (R)-5-(3-bromo-phenyl)-2,2,5-trimethyl-morpholin-3-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(R)-5-(3-bromo-phenyl)-4-(4-methoxy-benzyl)-2,2,5-trimethyl-morpholin-3-one;
With
trifluorormethanesulfonic acid; methoxybenzene; trifluoroacetic acid;
at 73 ℃;
With
sodium hydrogencarbonate;
In
water;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.58 h / 0 °C
1.2: -4 - 20 °C
2.1: lithium diisopropyl amide / tetrahydrofuran / -75 °C / Inert atmosphere
2.2: Cooling
3.1: lithium diisopropyl amide / tetrahydrofuran / 0.25 h / -75 °C / Inert atmosphere
4.1: trifluoroacetic acid; methoxybenzene; trifluorormethanesulfonic acid / 73 °C
With
trifluorormethanesulfonic acid; potassium tert-butylate; methoxybenzene; trifluoroacetic acid; lithium diisopropyl amide;
In
tetrahydrofuran; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: lithium diisopropyl amide / tetrahydrofuran / -75 °C / Inert atmosphere
1.2: Cooling
2.1: lithium diisopropyl amide / tetrahydrofuran / 0.25 h / -75 °C / Inert atmosphere
3.1: trifluoroacetic acid; methoxybenzene; trifluorormethanesulfonic acid / 73 °C
With
trifluorormethanesulfonic acid; methoxybenzene; trifluoroacetic acid; lithium diisopropyl amide;
In
tetrahydrofuran;
