5'-O-(methoxytrityl)-2'-O-(tetrahydropyranyl)-O⁶-(di-n-butylthioxophosphoranyl)-N²-benzoylguanosine

Base Information

• Chemical Name: 5'-O-(methoxytrityl)-2'-O-(tetrahydropyranyl)-O⁶-(di-n-butylthioxophosphoranyl)-N²-benzoylguanosine
• CAS No.: 79970-32-4
• Molecular Formula: C₅₀H₅₈N₅O₈PS
• Molecular Weight: 920.079

Synonyms:5'-O-(methoxytrityl)-2'-O-(tetrahydropyranyl)-O⁶-(di-n-butylthioxophosphoranyl)-N²-benzoylguanosine

Chemical Property of 5'-O-(methoxytrityl)-2'-O-(tetrahydropyranyl)-O⁶-(di-n-butylthioxophosphoranyl)-N²-benzoylguanosine

Chemical Property:

Purity/Quality:

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Technology Process of 5'-O-(methoxytrityl)-2'-O-(tetrahydropyranyl)-O⁶-(di-n-butylthioxophosphoranyl)-N²-benzoylguanosine

There total 2 articles about 5'-O-(methoxytrityl)-2'-O-(tetrahydropyranyl)-O⁶-(di-n-butylthioxophosphoranyl)-N²-benzoylguanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

5'-O-(methoxytrityl)-2'-O-(tetrahydropyranyl)-N2-benzoylguanosine (79970-27-7) + di-n-butylthioxophosphoranyl bromide (55656-88-7) → 5'-O-(methoxytrityl)-2'-O-(tetrahydropyranyl)-O6-(di-n-butylthioxophosphoranyl)-N2-benzoylguanosine (79970-32-4)

Guidance literature:

With dmap; triethylamine; In dichloromethane; for 4h; Ambient temperature;

DOI:10.1021/jo00342a042

Reference yield:

mono-4-methoxytrityl chloride (14470-28-1) → 5'-O-(methoxytrityl)-2'-O-(tetrahydropyranyl)-O6-(di-n-butylthioxophosphoranyl)-N2-benzoylguanosine (79970-32-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / pyridine / 72 h / Ambient temperature

2: 96 percent / triethylamine, DMAP / CH₂Cl₂ / 4 h / Ambient temperature

With pyridine; dmap; triethylamine; In dichloromethane;

DOI:10.1021/jo00342a042

upstream raw materials:

5'-O-(methoxytrityl)-2'-O-(tetrahydropyranyl)-N²-benzoylguanosine

di-n-butylthioxophosphoranyl bromide

mono-4-methoxytrityl chloride

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