1-{5'-O-[bis(4-methoxyphenyl)phyenylmethyl]-β-D-ribofuranosyl}-1,5-dihydro-6-[(phenoxyacetyl)amino]-4H-imidazo[4,5-c]pyridin-4-one

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Chemical Name:1-{5'-O-[bis(4-methoxyphenyl)phyenylmethyl]-β-D-ribofuranosyl}-1,5-dihydro-6-[(phenoxyacetyl)amino]-4H-imidazo[4,5-c]pyridin-4-one
CAS No.:663616-70-4
Molecular Formula:C₄₀H₃₈N₄O₉
Molecular Weight:718.763
Hs Code.:

Synonyms:1-{5'-O-[bis(4-methoxyphenyl)phyenylmethyl]-β-D-ribofuranosyl}-1,5-dihydro-6-[(phenoxyacetyl)amino]-4H-imidazo[4,5-c]pyridin-4-one

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Chemical Property of 1-{5'-O-[bis(4-methoxyphenyl)phyenylmethyl]-β-D-ribofuranosyl}-1,5-dihydro-6-[(phenoxyacetyl)amino]-4H-imidazo[4,5-c]pyridin-4-one

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Technology Process of 1-{5'-O-[bis(4-methoxyphenyl)phyenylmethyl]-β-D-ribofuranosyl}-1,5-dihydro-6-[(phenoxyacetyl)amino]-4H-imidazo[4,5-c]pyridin-4-one

There total 5 articles about 1-{5'-O-[bis(4-methoxyphenyl)phyenylmethyl]-β-D-ribofuranosyl}-1,5-dihydro-6-[(phenoxyacetyl)amino]-4H-imidazo[4,5-c]pyridin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 663616-68-0
1,5-dihydro-6-[(phenoxyacetyl)amino]-1-(β-D-ribofuranosyl)-4H-imidazo[4,5-c]pyridin-4-one

: 663616-70-4
1-{5'-O-[bis(4-methoxyphenyl)phyenylmethyl]-β-D-ribofuranosyl}-1,5-dihydro-6-[(phenoxyacetyl)amino]-4H-imidazo[4,5-c]pyridin-4-one

Guidance literature:: With pyridine; at 20 ℃; for 4h;
DOI:10.1002/hlca.200390222

Reference yield:

: 6974-32-9
1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose

: 663616-70-4
1-{5'-O-[bis(4-methoxyphenyl)phyenylmethyl]-β-D-ribofuranosyl}-1,5-dihydro-6-[(phenoxyacetyl)amino]-4H-imidazo[4,5-c]pyridin-4-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: hexamethyldisilazane; (NH₄)2SO₄ / 3 h / Heating

1.2: 92 percent / SnCl₄ / acetonitrile / 3 h / 20 °C

2.1: 70 percent / NH₃ / methanol / 48 h / 120 °C

3.1: 1,1,1,3,3,3-hexamethyldisilazane / dimethylformamide / 0.5 h / 20 °C

3.2: pyridine / 3 h

3.3: 72 percent / pyridine; H₂O / 0.25 h / 0 °C

4.1: 72 percent / pyridine / 4 h / 20 °C

With pyridine; ammonium sulfate; ammonia; 1,1,1,3,3,3-hexamethyl-disilazane; In methanol; N,N-dimethyl-formamide; 1.2: Vorbrueggen glycosylation;
DOI:10.1002/hlca.200390222

Reference yield:

: 22566-91-2
1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-imidazo[4,5-c]pyridin-4(5H)-one

: 663616-70-4
1-{5'-O-[bis(4-methoxyphenyl)phyenylmethyl]-β-D-ribofuranosyl}-1,5-dihydro-6-[(phenoxyacetyl)amino]-4H-imidazo[4,5-c]pyridin-4-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1,1,1,3,3,3-hexamethyldisilazane / dimethylformamide / 0.5 h / 20 °C

1.2: pyridine / 3 h

1.3: 72 percent / pyridine; H₂O / 0.25 h / 0 °C

2.1: 72 percent / pyridine / 4 h / 20 °C

With pyridine; 1,1,1,3,3,3-hexamethyl-disilazane; In N,N-dimethyl-formamide;
DOI:10.1002/hlca.200390222