7-(4-chlorophenyl)-1,3-dimethyl-5-phenylpyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione

Base Information

Chemical Name:7-(4-chlorophenyl)-1,3-dimethyl-5-phenylpyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione
CAS No.:70328-92-6
Molecular Formula:C₂₀H₁₅ClN₄O₂
Molecular Weight:378.818
Hs Code.:

Synonyms:7-(4-chlorophenyl)-1,3-dimethyl-5-phenylpyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione

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Chemical Property of 7-(4-chlorophenyl)-1,3-dimethyl-5-phenylpyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione

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Technology Process of 7-(4-chlorophenyl)-1,3-dimethyl-5-phenylpyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione

There total 4 articles about 7-(4-chlorophenyl)-1,3-dimethyl-5-phenylpyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 4-chloro-N-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)benzimidamide

: 100-51-6,185532-71-2
benzyl alcohol

: 70328-92-6
7-(4-chlorophenyl)-1,3-dimethyl-5-phenylpyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione

Guidance literature:: With [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; caesium carbonate; In dimethyl sulfoxide; at 110 ℃; for 15h; Sealed tube;
DOI:10.1002/aoc.6087

Reference yield: 80.0%

: 4-chloro-N-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)benzimidamide

: 108-88-3,15644-74-3,16713-13-6
toluene

: 70328-92-6
7-(4-chlorophenyl)-1,3-dimethyl-5-phenylpyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione

Guidance literature:: With tert.-butylhydroperoxide; caesium carbonate; at 100 ℃; for 15h; Green chemistry;
DOI:10.1039/c9ra06625j

Reference yield:

: 6972-27-6
1,3-Dimethyl-6-chlorouracil

: 70328-92-6
7-(4-chlorophenyl)-1,3-dimethyl-5-phenylpyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tert-butyl alcohol / 24 h / 80 °C / Sealed tube; Inert atmosphere

2: [bis(acetoxy)iodo]benzene; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; caesium carbonate; 1,1,1,3',3',3'-hexafluoro-propanol / 15 h / 100 °C / Microwave irradiation; Sealed tube

With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; 1,1,1,3',3',3'-hexafluoro-propanol; [bis(acetoxy)iodo]benzene; caesium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tert-butyl alcohol;
DOI:10.1080/00397911.2021.2024854