4-methyl-6-amino-8-[5'-O-(phenylphosphoryl (P->N)-L-valine methyl ester)-2',3'-O-dilevylinyl-β-D-ribofuranosyl]pyrrolo[4,3,2-d]pyrimidino[4,5-c]pyridazine

Base Information

Chemical Name:4-methyl-6-amino-8-[5'-O-(phenylphosphoryl (P->N)-L-valine methyl ester)-2',3'-O-dilevylinyl-β-D-ribofuranosyl]pyrrolo[4,3,2-d]pyrimidino[4,5-c]pyridazine
CAS No.:1065474-61-4
Molecular Formula:C₃₅H₄₄N₇O₁₂P
Molecular Weight:785.748
Hs Code.:

4-methyl-6-amino-8-[5'-O-(phenylphosphoryl (P->N)-L-valine methyl ester)-2',3'-O-dilevylinyl-β-D-ribofuranosyl]pyrrolo[4,3,2-d]pyrimidino[4,5-c]pyridazine

Synonyms:4-methyl-6-amino-8-[5'-O-(phenylphosphoryl (P->N)-L-valine methyl ester)-2',3'-O-dilevylinyl-β-D-ribofuranosyl]pyrrolo[4,3,2-d]pyrimidino[4,5-c]pyridazine

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Chemical Property of 4-methyl-6-amino-8-[5'-O-(phenylphosphoryl (P->N)-L-valine methyl ester)-2',3'-O-dilevylinyl-β-D-ribofuranosyl]pyrrolo[4,3,2-d]pyrimidino[4,5-c]pyridazine

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Technology Process of 4-methyl-6-amino-8-[5'-O-(phenylphosphoryl (P->N)-L-valine methyl ester)-2',3'-O-dilevylinyl-β-D-ribofuranosyl]pyrrolo[4,3,2-d]pyrimidino[4,5-c]pyridazine

There total 8 articles about 4-methyl-6-amino-8-[5'-O-(phenylphosphoryl (P->N)-L-valine methyl ester)-2',3'-O-dilevylinyl-β-D-ribofuranosyl]pyrrolo[4,3,2-d]pyrimidino[4,5-c]pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1065474-37-4
4-methyl-6-amino-8-[2',3-O'-dilevylinyl-β-D-ribofuranosyl]pyrrolo[4,3,2-d]pyrimidino[4,5-c]pyridazine

: 261910-17-2
chlorophenylphosphoryl (P->N)-L-valine methyl ester

: 1065474-61-4
4-methyl-6-amino-8-[5'-O-(phenylphosphoryl (P->N)-L-valine methyl ester)-2',3'-O-dilevylinyl-β-D-ribofuranosyl]pyrrolo[4,3,2-d]pyrimidino[4,5-c]pyridazine

Guidance literature:: With 1-methyl-1H-imidazole; In tetrahydrofuran; at 20 ℃; for 5h; Inert atmosphere;
DOI:10.1080/00397911.2010.524342

Reference yield:

: 1065474-32-9
5'-O-(tert-butyldimethylsilyl)-[6-amino-4-methyl-8-(β-D-ribofuranosyl)pyrrolo[4,3,2-de]pyrimido[4,5-c]pyridazine]

: 1065474-61-4
4-methyl-6-amino-8-[5'-O-(phenylphosphoryl (P->N)-L-valine methyl ester)-2',3'-O-dilevylinyl-β-D-ribofuranosyl]pyrrolo[4,3,2-d]pyrimidino[4,5-c]pyridazine

Guidance literature:: Multi-step reaction with 3 steps

1: dicyclohexyl-carbodiimide / ethyl acetate; N,N-dimethyl-formamide / 1.5 h / 20 °C / Inert atmosphere

2: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran / 1.5 h / 20 °C / Inert atmosphere

3: 1-methyl-1H-imidazole / tetrahydrofuran / 5 h / 20 °C / Inert atmosphere

With 1-methyl-1H-imidazole; tetrabutyl ammonium fluoride; acetic acid; dicyclohexyl-carbodiimide; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1080/00397911.2010.524342

Reference yield:

: 35943-35-2
triciribine

: 1065474-61-4
4-methyl-6-amino-8-[5'-O-(phenylphosphoryl (P->N)-L-valine methyl ester)-2',3'-O-dilevylinyl-β-D-ribofuranosyl]pyrrolo[4,3,2-d]pyrimidino[4,5-c]pyridazine

Guidance literature:: Multi-step reaction with 4 steps

1: 2,2-bis(hydroxymethyl)propionic acid / N,N-dimethyl-formamide / 20 h / 20 °C / Inert atmosphere

2: dicyclohexyl-carbodiimide / ethyl acetate; N,N-dimethyl-formamide / 1.5 h / 20 °C / Inert atmosphere

3: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran / 1.5 h / 20 °C / Inert atmosphere

4: 1-methyl-1H-imidazole / tetrahydrofuran / 5 h / 20 °C / Inert atmosphere

With 1-methyl-1H-imidazole; 2,2-bis(hydroxymethyl)propionic acid; tetrabutyl ammonium fluoride; acetic acid; dicyclohexyl-carbodiimide; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1080/00397911.2010.524342