3-amino-2-(4-methylphenyl)aminopyrazino[2',3':4,5]-thieno[3,2-d]pyrimidin-4(3H)-one

Base Information

• Chemical Name: 3-amino-2-(4-methylphenyl)aminopyrazino[2',3':4,5]-thieno[3,2-d]pyrimidin-4(3H)-one
• CAS No.: 1010433-27-8
• Molecular Formula: C₁₅H₁₂N₆OS
• Molecular Weight: 324.366

Synonyms:3-amino-2-(4-methylphenyl)aminopyrazino[2',3':4,5]-thieno[3,2-d]pyrimidin-4(3H)-one

Chemical Property of 3-amino-2-(4-methylphenyl)aminopyrazino[2',3':4,5]-thieno[3,2-d]pyrimidin-4(3H)-one

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Technology Process of 3-amino-2-(4-methylphenyl)aminopyrazino[2',3':4,5]-thieno[3,2-d]pyrimidin-4(3H)-one

There total 1 articles about 3-amino-2-(4-methylphenyl)aminopyrazino[2',3':4,5]-thieno[3,2-d]pyrimidin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

ethyl 7-(triphenylphosphoranylideneamino)-thieno[2,3-b]pyrazine-6-carboxylate (916898-69-6) + p-Tolylisocyanate (622-58-2,374675-64-6) → 3-amino-2-(4-methylphenyl)aminopyrazino[2',3':4,5]-thieno[3,2-d]pyrimidin-4(3H)-one (1010433-27-8)

Guidance literature:

ethyl 7-(triphenylphosphoranylideneamino)-thieno[2,3-b]pyrazine-6-carboxylate; p-Tolylisocyanate; In tetrahydrofuran; at 20 ℃; for 3h;

With hydrazine hydrate; In ethanol; at 20 ℃; for 0.5h; Further stages.;

DOI:10.1016/j.tet.2007.11.059

Reference yield: 75.0%

3-amino-2-(4-methylphenyl)aminopyrazino[2',3':4,5]-thieno[3,2-d]pyrimidin-4(3H)-one (1010433-27-8) + triphenylphosphine (603-35-0) → 2-(4-methylphenyl)amino-3-(triphenylphosphoranylidene-amino)pyrazino[2',3':4,5]-thieno[3,2-d]pyrimidin-4(3H)-one (1010433-30-3)

Guidance literature:

With hexachloroethane; triethylamine; In toluene; at 100 ℃; for 48h;

DOI:10.1016/j.tet.2007.11.059

Reference yield: 71.0%

3-amino-2-(4-methylphenyl)aminopyrazino[2',3':4,5]-thieno[3,2-d]pyrimidin-4(3H)-one (1010433-27-8) + dichloromethylenedimethyliminium chloride (33842-02-3,529510-96-1) → 2-(N,N-dimethylamino)-3-(4-methylphenyl)pyrazino-[2',3':4,5]thieno[3,2-d]1,2,4-triazolo[1,5-a]pyrimidin-10(3H)-one (1010433-65-4)

Guidance literature:

In dichloromethane; for 1h; Heating;

DOI:10.1016/j.tet.2007.11.059

upstream raw materials:

ethyl 7-(triphenylphosphoranylideneamino)-thieno[2,3-b]pyrazine-6-carboxylate

p-Tolylisocyanate

Downstream raw materials:

2-(N,N-dimethylamino)-3-(4-methylphenyl)pyrazino-[2',3':4,5]thieno[3,2-d]1,2,4-triazolo[1,5-a]pyrimidin-10(3H)-one

2-(4-methylphenyl)amino-3-(triphenylphosphoranylidene-amino)pyrazino[2',3':4,5]-thieno[3,2-d]pyrimidin-4(3H)-one

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