Technology Process of α4-O-benzyl-6-(trifluoromethyl)pyridoxine
There total 3 articles about α4-O-benzyl-6-(trifluoromethyl)pyridoxine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
5%-palladium/activated carbon; hydrogen; acetic acid;
In
ethanol;
at 20 ℃;
for 24h;
under 1551.49 Torr;
DOI:10.1021/jm300520q
- Guidance literature:
-
Multi-step reaction with 2 steps
1: copper(l) iodide; potassium fluoride / 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide / 24 h / 80 °C / Inert atmosphere; Darkness; Sealed tube
2: 5%-palladium/activated carbon; hydrogen; acetic acid / ethanol / 24 h / 20 °C / 1551.49 Torr
With
potassium fluoride; copper(l) iodide; 5%-palladium/activated carbon; hydrogen; acetic acid;
In
1-methyl-pyrrolidin-2-one; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm300520q
- Guidance literature:
-
Multi-step reaction with 4 steps
1: iodine; potassium carbonate / water / 20 °C / Darkness
2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 20 °C
3: copper(l) iodide; potassium fluoride / 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide / 24 h / 80 °C / Inert atmosphere; Darkness; Sealed tube
4: 5%-palladium/activated carbon; hydrogen; acetic acid / ethanol / 24 h / 20 °C / 1551.49 Torr
With
potassium fluoride; copper(l) iodide; 5%-palladium/activated carbon; hydrogen; iodine; sodium hydride; potassium carbonate; acetic acid;
In
1-methyl-pyrrolidin-2-one; ethanol; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm300520q
